DegronMD - Q96NC0(ZMAT2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q121H	TCGA-4P-AA8J	HNSC	TCGA	ERSTLDQVK	DEG_APCC_DBOX_1	115:123	Mutation altering degron motif	0.647
p.Q121H	DO52027	HNSC	ICGC	ERSTLDQVK	DEG_APCC_DBOX_1	115:123	Mutation altering degron motif	0.647
p.M133L	TCGA-A5-A0G2	UCEC	TCGA	ERSTLDQVK	DEG_APCC_DBOX_1	115:123	Mutation rewiring degron network	0.0556
p.M133L	DO41235	UCEC	ICGC	ERSTLDQVK	DEG_APCC_DBOX_1	115:123	Mutation rewiring degron network	0.0556
p.R113H	TCGA-AP-A051	UCEC	TCGA	ERSTLDQVK	DEG_APCC_DBOX_1	115:123	Mutation rewiring degron network	0.2778
p.R113H	DO42673	UCEC	ICGC	ERSTLDQVK	DEG_APCC_DBOX_1	115:123	Mutation rewiring degron network	0.2778
p.R106K	TCGA-AZ-6599	COAD	TCGA	ERSTLDQVK	DEG_APCC_DBOX_1	115:123	Mutation rewiring degron network	0.0833
p.R106K	DO10606	COAD	ICGC	ERSTLDQVK	DEG_APCC_DBOX_1	115:123	Mutation rewiring degron network	0.0833
p.R125L	DO228971	LICA	ICGC	ERSTLDQVK	DEG_APCC_DBOX_1	115:123	Mutation rewiring degron network	0.2778
p.G109C	DO229015	LICA	ICGC	ERSTLDQVK	DEG_APCC_DBOX_1	115:123	Mutation rewiring degron network	0.1667
p.R113P	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	ERSTLDQVK	DEG_APCC_DBOX_1	115:123	Mutation rewiring degron network	0.2778
p.R113P	ACH-000893	Lung Cancer	CCLE	ERSTLDQVK	DEG_APCC_DBOX_1	115:123	Mutation rewiring degron network	0.2778
p.R113P	NCI-H1651	lung	COSMIC	ERSTLDQVK	DEG_APCC_DBOX_1	115:123	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons