DegronMD

Uniprot ID: Q96NC0

Source protein: Zinc finger matrin-type protein 2

Source gene: ZMAT2

Class: DEG_APCC_DBOX_1

Location: 115:123

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7197

ASA_SCORE: 69.3556

COIL: 0.2747

CONS_SCORE: 0.6359

DSS_SCORE: 0.4357

HELIX: 0.5774

FCONS_SCORE: 1.1585

RIG_SCORE: 0.7644

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q121H	TCGA-4P-AA8J	HNSC	TCGA	ERSTLDQVK	DEG_APCC_DBOX_1	0.647
p.Q121H	DO52027	HNSC	ICGC	ERSTLDQVK	DEG_APCC_DBOX_1	0.647
p.M133L	TCGA-A5-A0G2	UCEC	TCGA	ERSTLDQVK	DEG_APCC_DBOX_1	0.0556
p.M133L	DO41235	UCEC	ICGC	ERSTLDQVK	DEG_APCC_DBOX_1	0.0556
p.R113H	TCGA-AP-A051	UCEC	TCGA	ERSTLDQVK	DEG_APCC_DBOX_1	0.2778
p.R113H	DO42673	UCEC	ICGC	ERSTLDQVK	DEG_APCC_DBOX_1	0.2778
p.R106K	TCGA-AZ-6599	COAD	TCGA	ERSTLDQVK	DEG_APCC_DBOX_1	0.0833
p.R106K	DO10606	COAD	ICGC	ERSTLDQVK	DEG_APCC_DBOX_1	0.0833
p.R125L	DO228971	LICA	ICGC	ERSTLDQVK	DEG_APCC_DBOX_1	0.2778
p.G109C	DO229015	LICA	ICGC	ERSTLDQVK	DEG_APCC_DBOX_1	0.1667
p.R113P	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	ERSTLDQVK	DEG_APCC_DBOX_1	0.2778
p.R113P	ACH-000893	Lung Cancer	CCLE	ERSTLDQVK	DEG_APCC_DBOX_1	0.2778
p.R113P	NCI-H1651	lung	COSMIC	ERSTLDQVK	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96NC0	Zinc finger matrin-type protein 2	DEG_APCC_DBOX_1	115:123	ERSTLDQVK	APC,CDC20,FZR1	0.7197	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons