DegronMD - Q96NT0(CCDC115)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K105N	TCGA-17-Z014	LUAD	TCGA	PTKTPEPE	DEG_SCF_FBW7_2	107:114	Mutation rewiring degron network	0.2778
p.K105N	TCGA-63-6202	LUSC	TCGA	PTKTPEPE	DEG_SCF_FBW7_2	107:114	Mutation rewiring degron network	0.2778
p.R103M	TCGA-21-1081	LUSC	TCGA	PTKTPEPE	DEG_SCF_FBW7_2	107:114	Mutation rewiring degron network	0.2222
p.R97S	TCGA-MN-A4N4	LUAD	TCGA	PTKTPEPE	DEG_SCF_FBW7_2	107:114	Mutation rewiring degron network	0.0556
p.K104Q	DO231114	LUSC	ICGC	PTKTPEPE	DEG_SCF_FBW7_2	107:114	Mutation rewiring degron network	0.25
p.R98M	DO26930	LUSC	ICGC	PTKTPEPE	DEG_SCF_FBW7_2	107:114	Mutation rewiring degron network	0.0833
p.K100N	DO26560	LUSC	ICGC	PTKTPEPE	DEG_SCF_FBW7_2	107:114	Mutation rewiring degron network	0.1389
p.R104C	SIDM01768	Melanoma	GDSC	PTKTPEPE	DEG_SCF_FBW7_2	107:114	Mutation rewiring degron network	0.25
p.R104C	ACH-000899	Skin Cancer	CCLE	PTKTPEPE	DEG_SCF_FBW7_2	107:114	Mutation rewiring degron network	0.25
p.T108S	ACH-001302	Neuroblastoma	CCLE	PTKTPEPE	DEG_SCF_FBW7_2	107:114	Mutation altering degron motif	0.6005
p.P113L	ACH-001786	Colon/Colorectal Cancer	CCLE	PTKTPEPE	DEG_SCF_FBW7_2	107:114	Mutation altering degron motif	0.6471

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons