DegronMD

Uniprot ID: Q96NT0

Source protein: Coiled-coil domain-containing protein 115

Source gene: CCDC115

Class: DEG_SCF_FBW7_2

Location: 107:114

E3 ligase: FBXW7

DEGRON score: 0.6666

ASA_SCORE: 110.1875

COIL: 0.9474

CONS_SCORE: 0.3783

DSS_SCORE: 0.801

HELIX: 0.0334

FCONS_SCORE: 0.6649

RIG_SCORE: 0.5724

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K105N	TCGA-17-Z014	LUAD	TCGA	PTKTPEPE	DEG_SCF_FBW7_2	0.2778
p.K105N	TCGA-63-6202	LUSC	TCGA	PTKTPEPE	DEG_SCF_FBW7_2	0.2778
p.R103M	TCGA-21-1081	LUSC	TCGA	PTKTPEPE	DEG_SCF_FBW7_2	0.2222
p.R97S	TCGA-MN-A4N4	LUAD	TCGA	PTKTPEPE	DEG_SCF_FBW7_2	0.0556
p.K104Q	DO231114	LUSC	ICGC	PTKTPEPE	DEG_SCF_FBW7_2	0.25
p.R98M	DO26930	LUSC	ICGC	PTKTPEPE	DEG_SCF_FBW7_2	0.0833
p.K100N	DO26560	LUSC	ICGC	PTKTPEPE	DEG_SCF_FBW7_2	0.1389
p.R104C	SIDM01768	Melanoma	GDSC	PTKTPEPE	DEG_SCF_FBW7_2	0.25
p.R104C	ACH-000899	Skin Cancer	CCLE	PTKTPEPE	DEG_SCF_FBW7_2	0.25
p.T108S	ACH-001302	Neuroblastoma	CCLE	PTKTPEPE	DEG_SCF_FBW7_2	0.6005
p.P113L	ACH-001786	Colon/Colorectal Cancer	CCLE	PTKTPEPE	DEG_SCF_FBW7_2	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96NT0	Coiled-coil domain-containing protein 115	DEG_SCF_FBW7_2	107:114	PTKTPEPE	FBXW7	0.6666	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons