DegronMD - Q96NT3(GUCD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D232G	TCGA-AP-A0LM	UCEC	TCGA	LFVYLD	LIG_APCC_ABBA_1	234:239	Mutation rewiring degron network	0.2778
p.D232G	DO43306	UCEC	ICGC	LFVYLD	LIG_APCC_ABBA_1	234:239	Mutation rewiring degron network	0.2778
p.G228D	TCGA-B5-A3FC	UCEC	TCGA	LFVYLD	LIG_APCC_ABBA_1	234:239	Mutation rewiring degron network	0.1667
p.G228D	DO41871	UCEC	ICGC	LFVYLD	LIG_APCC_ABBA_1	234:239	Mutation rewiring degron network	0.1667
p.F235C	TCGA-DF-A2KU	UCEC	TCGA	LFVYLD	LIG_APCC_ABBA_1	234:239	Mutation altering degron motif	0.5996
p.F235C	DO223286	UCEC	ICGC	LFVYLD	LIG_APCC_ABBA_1	234:239	Mutation altering degron motif	0.5996
p.F235I	TCGA-G7-7502	KIRP	TCGA	LFVYLD	LIG_APCC_ABBA_1	234:239	Mutation altering degron motif	0.6304
p.F235I	DO20873	KIRP	ICGC	LFVYLD	LIG_APCC_ABBA_1	234:239	Mutation altering degron motif	0.6304
p.T225I	DO11854	GBM	ICGC	LFVYLD	LIG_APCC_ABBA_1	234:239	Mutation rewiring degron network	0.0833
p.R247C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LFVYLD	LIG_APCC_ABBA_1	234:239	Mutation rewiring degron network	0.1111
p.R247C	ACH-001127	Leukemia	CCLE	LFVYLD	LIG_APCC_ABBA_1	234:239	Mutation rewiring degron network	0.1111
p.R247C	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LFVYLD	LIG_APCC_ABBA_1	234:239	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons