DegronMD

Uniprot ID: Q96NT3

Source protein: Protein GUCD1

Source gene: GUCD1

Class: LIG_APCC_ABBA_1

Location: 234:239

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.981

ASA_SCORE: 47.6167

COIL: 0.3687

CONS_SCORE: 0.4732

DSS_SCORE: 0.5988

HELIX: 0.016

FCONS_SCORE: 0.7728

RIG_SCORE: 0.9333

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D232G	TCGA-AP-A0LM	UCEC	TCGA	LFVYLD	LIG_APCC_ABBA_1	0.2778
p.D232G	DO43306	UCEC	ICGC	LFVYLD	LIG_APCC_ABBA_1	0.2778
p.G228D	TCGA-B5-A3FC	UCEC	TCGA	LFVYLD	LIG_APCC_ABBA_1	0.1667
p.G228D	DO41871	UCEC	ICGC	LFVYLD	LIG_APCC_ABBA_1	0.1667
p.F235C	TCGA-DF-A2KU	UCEC	TCGA	LFVYLD	LIG_APCC_ABBA_1	0.5996
p.F235C	DO223286	UCEC	ICGC	LFVYLD	LIG_APCC_ABBA_1	0.5996
p.F235I	TCGA-G7-7502	KIRP	TCGA	LFVYLD	LIG_APCC_ABBA_1	0.6304
p.F235I	DO20873	KIRP	ICGC	LFVYLD	LIG_APCC_ABBA_1	0.6304
p.T225I	DO11854	GBM	ICGC	LFVYLD	LIG_APCC_ABBA_1	0.0833
p.R247C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LFVYLD	LIG_APCC_ABBA_1	0.1111
p.R247C	ACH-001127	Leukemia	CCLE	LFVYLD	LIG_APCC_ABBA_1	0.1111
p.R247C	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LFVYLD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96NT3	Protein GUCD1	LIG_APCC_ABBA_1	234:239	LFVYLD	APC,CDC20,FZR1	0.981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons