DegronMD - Q96NZ1(FOXN4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D276N	TCGA-AG-3892	READ	TCGA	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.0556
p.D276N	DO36394	READ	ICGC	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.0556
p.N299S	TCGA-FS-A1ZZ	SKCM	TCGA	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1944
p.N299S	DO230343	COCA	ICGC	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1944
p.N299S	DO37412	SKCM	ICGC	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1944
p.R295Q	TCGA-XK-AAIW	PRAD	TCGA	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.3056
p.T302M	DO223133	ESCA	ICGC	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1111
p.T302M	DO38201	STAD	ICGC	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1111
p.A282S	DO26695	LUSC	ICGC	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.2222
p.T286A	DO37409	SKCM	ICGC	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.7139
p.T286A	SW684	soft tissue	COSMIC	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.7139
p.T302A	DO50118	STAD	ICGC	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1111
p.E280G	SIDM01088	Endometrial Carcinoma	GDSC	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1667
p.E280G	ACH-000965	Endometrial/Uterine Cancer	CCLE	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1667
p.E280G	RL95-2	endometrium	COSMIC	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1667
p.N299K	SIDM00242	Osteosarcoma	GDSC	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1944
p.N299K	ACH-002067	Bone Cancer	CCLE	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1944
p.N299K	NOS-1	bone	COSMIC	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation rewiring degron network	0.1944
p.S289L	CHP-134	autonomic ganglia	COSMIC	KRKDLAAIH	DEG_APCC_DBOX_1	286:294	Mutation altering degron motif	0.7667

Kaplan plot for FOXN4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXN4

UniProt ID: Q96NZ1

Entrez ID: 121643

Protein name: Forkhead box protein N4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXN4 in