DegronMD

Uniprot ID: Q96NZ1

Source protein: Forkhead box protein N4

Source gene: FOXN4

Class: DEG_APCC_DBOX_1

Location: 286:294

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8207

ASA_SCORE: 84.5556

COIL: 0.3229

CONS_SCORE: 0.7234

DSS_SCORE: 0.4093

HELIX: 0.6618

FCONS_SCORE: 1.0461

RIG_SCORE: 0.7847

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D276N	TCGA-AG-3892	READ	TCGA	KRKDLAAIH	DEG_APCC_DBOX_1	0.0556
p.D276N	DO36394	READ	ICGC	KRKDLAAIH	DEG_APCC_DBOX_1	0.0556
p.N299S	TCGA-FS-A1ZZ	SKCM	TCGA	KRKDLAAIH	DEG_APCC_DBOX_1	0.1944
p.N299S	DO230343	COCA	ICGC	KRKDLAAIH	DEG_APCC_DBOX_1	0.1944
p.N299S	DO37412	SKCM	ICGC	KRKDLAAIH	DEG_APCC_DBOX_1	0.1944
p.R295Q	TCGA-XK-AAIW	PRAD	TCGA	KRKDLAAIH	DEG_APCC_DBOX_1	0.3056
p.T302M	DO223133	ESCA	ICGC	KRKDLAAIH	DEG_APCC_DBOX_1	0.1111
p.T302M	DO38201	STAD	ICGC	KRKDLAAIH	DEG_APCC_DBOX_1	0.1111
p.A282S	DO26695	LUSC	ICGC	KRKDLAAIH	DEG_APCC_DBOX_1	0.2222
p.T286A	DO37409	SKCM	ICGC	KRKDLAAIH	DEG_APCC_DBOX_1	0.7139
p.T286A	SW684	soft_tissue	COSMIC	KRKDLAAIH	DEG_APCC_DBOX_1	0.7139
p.T302A	DO50118	STAD	ICGC	KRKDLAAIH	DEG_APCC_DBOX_1	0.1111
p.E280G	SIDM01088	Endometrial Carcinoma	GDSC	KRKDLAAIH	DEG_APCC_DBOX_1	0.1667
p.E280G	ACH-000965	Endometrial/Uterine Cancer	CCLE	KRKDLAAIH	DEG_APCC_DBOX_1	0.1667
p.E280G	RL95-2	endometrium	COSMIC	KRKDLAAIH	DEG_APCC_DBOX_1	0.1667
p.N299K	SIDM00242	Osteosarcoma	GDSC	KRKDLAAIH	DEG_APCC_DBOX_1	0.1944
p.N299K	ACH-002067	Bone Cancer	CCLE	KRKDLAAIH	DEG_APCC_DBOX_1	0.1944
p.N299K	NOS-1	bone	COSMIC	KRKDLAAIH	DEG_APCC_DBOX_1	0.1944
p.S289L	CHP-134	autonomic_ganglia	COSMIC	KRKDLAAIH	DEG_APCC_DBOX_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96NZ1	Forkhead box protein N4	DEG_APCC_DBOX_1	286:294	KRKDLAAIH	APC,CDC20,FZR1	0.8207	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons