DegronMD - Q96NZ9(PRAP1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P116A	TCGA-44-6777	LUAD	TCGA	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1111
p.V136E	TCGA-55-7281	LUAD	TCGA	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.2222
p.E124K	TCGA-EE-A29E	SKCM	TCGA	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.591
p.R125M	TCGA-L5-A8NM	ESCA	TCGA	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.8632
p.V137E	DO25985	LUAD	ICGC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1944
p.P117A	DO23645	LUAD	ICGC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1389
p.E125K	DO37831	SKCM	ICGC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.7022
p.P116L	SIDM00656	Burkitt's Lymphoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1111
p.P116L	SIDM00654	Small Cell Lung Carcinoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1111
p.P116L	SIDM00844	Burkitt's Lymphoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1111
p.P116L	SIDM00793	Burkitt's Lymphoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1111
p.P116L	SIDM01173	Rhabdomyosarcoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1111
p.P116L	SIDM00641	Burkitt's Lymphoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1111
p.P116L	SIDM01752	Pancreatic Carcinoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1111
p.E123G	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.3056
p.E123G	ACH-000929	Lung Cancer	CCLE	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.3056
p.E123G	NCI-H2110	lung	COSMIC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.3056
p.E123K	SIDM00154	Mesothelioma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.3056
p.E123K	ACH-002130	Lung Cancer	CCLE	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.3056
p.E123K	H2795	pleura	COSMIC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.3056
p.E124D	SIDM01322	Oral Cavity Carcinoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.5647
p.E124D	ACH-000735	Head and Neck Cancer	CCLE	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation altering degron motif	0.5647
p.L137P	SIDM00228	Thyroid Gland Carcinoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1944
p.L137P	ACH-000897	Thyroid Cancer	CCLE	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.1944
p.E114G	NCI-H2110	lung	COSMIC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0556
p.P141S	NCI-H250	lung	COSMIC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0833
p.E114K	H2795	pleura	COSMIC	ERPRLWVMP	DEG_APCC_DBOX_1	124:132	Mutation rewiring degron network	0.0556

Kaplan plot for PRAP1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRAP1

UniProt ID: Q96NZ9

Entrez ID: 118471

Protein name: Proline-rich acidic protein 1 (Epididymis tissue protein Li 178) (Uterine-specific proline-rich acidic protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PRAP1 in