DegronMD

Uniprot ID: Q96NZ9

Source protein: Proline-rich acidic protein 1

Source gene: PRAP1

Class: DEG_APCC_DBOX_1

Location: 124:132

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5518

ASA_SCORE: 90.9111

COIL: 0.8208

CONS_SCORE: 0.4862

DSS_SCORE: 0.6417

HELIX: 0.0819

FCONS_SCORE: 0.7222

RIG_SCORE: 0.7137

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P116A	TCGA-44-6777	LUAD	TCGA	ERPRLWVMP	DEG_APCC_DBOX_1	0.1111
p.V136E	TCGA-55-7281	LUAD	TCGA	ERPRLWVMP	DEG_APCC_DBOX_1	0.2222
p.E124K	TCGA-EE-A29E	SKCM	TCGA	ERPRLWVMP	DEG_APCC_DBOX_1	0.591
p.R125M	TCGA-L5-A8NM	ESCA	TCGA	ERPRLWVMP	DEG_APCC_DBOX_1	0.8632
p.V137E	DO25985	LUAD	ICGC	ERPRLWVMP	DEG_APCC_DBOX_1	0.1944
p.P117A	DO23645	LUAD	ICGC	ERPRLWVMP	DEG_APCC_DBOX_1	0.1389
p.E125K	DO37831	SKCM	ICGC	ERPRLWVMP	DEG_APCC_DBOX_1	0.7022
p.P116L	SIDM00656	Burkitt's Lymphoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	0.1111
p.P116L	SIDM00654	Small Cell Lung Carcinoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	0.1111
p.P116L	SIDM00844	Burkitt's Lymphoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	0.1111
p.P116L	SIDM00793	Burkitt's Lymphoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	0.1111
p.P116L	SIDM01173	Rhabdomyosarcoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	0.1111
p.P116L	SIDM00641	Burkitt's Lymphoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	0.1111
p.P116L	SIDM01752	Pancreatic Carcinoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	0.1111
p.E123G	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	0.3056
p.E123G	ACH-000929	Lung Cancer	CCLE	ERPRLWVMP	DEG_APCC_DBOX_1	0.3056
p.E123G	NCI-H2110	lung	COSMIC	ERPRLWVMP	DEG_APCC_DBOX_1	0.3056
p.E123K	SIDM00154	Mesothelioma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	0.3056
p.E123K	ACH-002130	Lung Cancer	CCLE	ERPRLWVMP	DEG_APCC_DBOX_1	0.3056
p.E123K	H2795	pleura	COSMIC	ERPRLWVMP	DEG_APCC_DBOX_1	0.3056
p.E124D	SIDM01322	Oral Cavity Carcinoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	0.5647
p.E124D	ACH-000735	Head and Neck Cancer	CCLE	ERPRLWVMP	DEG_APCC_DBOX_1	0.5647
p.L137P	SIDM00228	Thyroid Gland Carcinoma	GDSC	ERPRLWVMP	DEG_APCC_DBOX_1	0.1944
p.L137P	ACH-000897	Thyroid Cancer	CCLE	ERPRLWVMP	DEG_APCC_DBOX_1	0.1944
p.E114G	NCI-H2110	lung	COSMIC	ERPRLWVMP	DEG_APCC_DBOX_1	0.0556
p.P141S	NCI-H250	lung	COSMIC	ERPRLWVMP	DEG_APCC_DBOX_1	0.0833
p.E114K	H2795	pleura	COSMIC	ERPRLWVMP	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERPRLWVMP

Degron related mutations and impact score

Drug responses associated with PRAP1 mutations

All proteins holding degron of ERPRLWVMP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96NZ9	Proline-rich acidic protein 1	DEG_APCC_DBOX_1	124:132	ERPRLWVMP	APC,CDC20,FZR1	0.5518	More...