DegronMD - Q96P16(RPRD1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D201E	TCGA-AB-2883	LAML	TCGA	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation rewiring degron network	0.2222
p.D201E	DO21445	LAML	ICGC	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation rewiring degron network	0.2222
p.L200S	TCGA-BR-6452	STAD	TCGA	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation rewiring degron network	0.1944
p.L200S	DO38404	STAD	ICGC	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation rewiring degron network	0.1944
p.G209V	TCGA-CR-7371	HNSC	TCGA	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation altering degron motif	0.7532
p.G209V	DO15454	HNSC	ICGC	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation altering degron motif	0.7532
p.S198Y	TCGA-CV-A6JE	HNSC	TCGA	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation blocking phosphorylation signal	0.5833
p.S198Y	DO49046	HNSC	ICGC	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation blocking phosphorylation signal	0.5833
p.A219V	TCGA-E9-A1ND	BRCA	TCGA	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation rewiring degron network	0.0833
p.A219V	DO5780	BRCA	ICGC	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation rewiring degron network	0.0833
p.A219V	DO230934	LUSC	ICGC	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation rewiring degron network	0.0833
p.A219V	ACH-001061	Colon/Colorectal Cancer	CCLE	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation rewiring degron network	0.0833
p.L212F	TCGA-EX-A8YF	CESC	TCGA	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation rewiring degron network	0.2778
p.L212F	DO49970	CESC	ICGC	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation rewiring degron network	0.2778
p.S213F	TCGA-W3-AA1Q	SKCM	TCGA	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation rewiring degron network	0.25
p.S213F	DO219487	SKCM	ICGC	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation rewiring degron network	0.25
p.G209E	DO229050	LICA	ICGC	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation altering degron motif	0.7199
p.D201H	SIDM01174	Cervical Carcinoma	GDSC	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation rewiring degron network	0.2222
p.D201H	ACH-001402	Cervical Cancer	CCLE	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation rewiring degron network	0.2222
p.D201H	SW756	cervix	COSMIC	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation rewiring degron network	0.2222
p.Q215R	JHU-029	upper aerodigestive tract	COSMIC	DKESGE	DEG_Kelch_Keap1_1	205:210	Mutation rewiring degron network	0.1944

Kaplan plot for RPRD1A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RPRD1A

UniProt ID: Q96P16

Entrez ID: 55197

Protein name: Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RPRD1A in