DegronMD

Uniprot ID: Q96P16

Source protein: Regulation of nuclear pre-mRNA domain-containing protein 1A

Source gene: RPRD1A

Class: DEG_Kelch_Keap1_1

Location: 205:210

E3 ligase: KEAP1

DEGRON score: 0.6601

ASA_SCORE: 86.3667

COIL: 0.5502

CONS_SCORE: 0.497

DSS_SCORE: 0.3413

HELIX: 0.4468

FCONS_SCORE: 1.0852

RIG_SCORE: 0.7427

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D201E	TCGA-AB-2883	LAML	TCGA	DKESGE	DEG_Kelch_Keap1_1	0.2222
p.D201E	DO21445	LAML	ICGC	DKESGE	DEG_Kelch_Keap1_1	0.2222
p.L200S	TCGA-BR-6452	STAD	TCGA	DKESGE	DEG_Kelch_Keap1_1	0.1944
p.L200S	DO38404	STAD	ICGC	DKESGE	DEG_Kelch_Keap1_1	0.1944
p.G209V	TCGA-CR-7371	HNSC	TCGA	DKESGE	DEG_Kelch_Keap1_1	0.7532
p.G209V	DO15454	HNSC	ICGC	DKESGE	DEG_Kelch_Keap1_1	0.7532
p.S198Y	TCGA-CV-A6JE	HNSC	TCGA	DKESGE	DEG_Kelch_Keap1_1	0.5833
p.S198Y	DO49046	HNSC	ICGC	DKESGE	DEG_Kelch_Keap1_1	0.5833
p.A219V	TCGA-E9-A1ND	BRCA	TCGA	DKESGE	DEG_Kelch_Keap1_1	0.0833
p.A219V	DO5780	BRCA	ICGC	DKESGE	DEG_Kelch_Keap1_1	0.0833
p.A219V	DO230934	LUSC	ICGC	DKESGE	DEG_Kelch_Keap1_1	0.0833
p.A219V	ACH-001061	Colon/Colorectal Cancer	CCLE	DKESGE	DEG_Kelch_Keap1_1	0.0833
p.L212F	TCGA-EX-A8YF	CESC	TCGA	DKESGE	DEG_Kelch_Keap1_1	0.2778
p.L212F	DO49970	CESC	ICGC	DKESGE	DEG_Kelch_Keap1_1	0.2778
p.S213F	TCGA-W3-AA1Q	SKCM	TCGA	DKESGE	DEG_Kelch_Keap1_1	0.25
p.S213F	DO219487	SKCM	ICGC	DKESGE	DEG_Kelch_Keap1_1	0.25
p.G209E	DO229050	LICA	ICGC	DKESGE	DEG_Kelch_Keap1_1	0.7199
p.D201H	SIDM01174	Cervical Carcinoma	GDSC	DKESGE	DEG_Kelch_Keap1_1	0.2222
p.D201H	ACH-001402	Cervical Cancer	CCLE	DKESGE	DEG_Kelch_Keap1_1	0.2222
p.D201H	SW756	cervix	COSMIC	DKESGE	DEG_Kelch_Keap1_1	0.2222
p.Q215R	JHU-029	upper_aerodigestive_tract	COSMIC	DKESGE	DEG_Kelch_Keap1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96P16	Regulation of nuclear pre-mRNA domain-containing protein 1A	DEG_Kelch_Keap1_1	205:210	DKESGE	KEAP1	0.6601	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons