DegronMD - Q96P48(ARAP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A72T	TCGA-AP-A1DK	UCEC	TCGA	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.1389
p.A72T	DO42033	UCEC	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.1389
p.R59H	TCGA-AX-A3G9	UCEC	TCGA	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.7133
p.R59H	TCGA-D1-A167	UCEC	TCGA	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.7133
p.R59H	DO233894	GACA	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.7133
p.R59H	DO40978	UCEC	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.7133
p.R59H	DO41241	UCEC	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.7133
p.P71L	TCGA-B5-A3FC	UCEC	TCGA	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.1667
p.P71L	DO41871	UCEC	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.1667
p.P71L	ACH-000994	Endometrial/Uterine Cancer	CCLE	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.1667
p.A67T	TCGA-EI-6507	READ	TCGA	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.2778
p.A67T	DO36675	READ	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.2778
p.P75H	DO233641	GACA	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.0556
p.A47T	DO233864	GACA	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.0556
p.M75I	DO37432	SKCM	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.0556
p.S59N	DO42344	UCEC	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.7069
p.V51I	DO41235	UCEC	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.1667
p.P54S	SIDM00140	Melanoma	GDSC	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.25
p.P54S	ACH-000968	Skin Cancer	CCLE	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.25
p.A67V	SIDM00537	Colorectal Carcinoma	GDSC	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.2778
p.A67V	ACH-000982	Colon/Colorectal Cancer	CCLE	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.2778
p.A67V	ACH-001345	Colon/Colorectal Cancer	CCLE	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.2778
p.M51I	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.1667
p.M51I	ACH-000727	Lung Cancer	CCLE	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.1667
p.V60L	G-292_Clone_A141B1	bone	COSMIC	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation altering degron motif	0.6765
p.R66Q	OCI-LY7	haematopoietic and lymphoid tissue	COSMIC	RRRILAGLL	DEG_APCC_DBOX_1	57:65	Mutation rewiring degron network	0.3056

Kaplan plot for ARAP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARAP1

UniProt ID: Q96P48

Entrez ID: 116985

Protein name: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARAP1 in