DegronMD

Uniprot ID: Q96P48

Source protein: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

Source gene: ARAP1

Class: DEG_APCC_DBOX_1

Location: 57:65

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9774

ASA_SCORE: 62.8444

COIL: 0.105

CONS_SCORE: 0.3795

DSS_SCORE: 0.4117

HELIX: 0.8846

FCONS_SCORE: 1.052

RIG_SCORE: 0.7432

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A72T	TCGA-AP-A1DK	UCEC	TCGA	RRRILAGLL	DEG_APCC_DBOX_1	0.1389
p.A72T	DO42033	UCEC	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	0.1389
p.R59H	TCGA-AX-A3G9	UCEC	TCGA	RRRILAGLL	DEG_APCC_DBOX_1	0.7133
p.R59H	TCGA-D1-A167	UCEC	TCGA	RRRILAGLL	DEG_APCC_DBOX_1	0.7133
p.R59H	DO233894	GACA	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	0.7133
p.R59H	DO40978	UCEC	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	0.7133
p.R59H	DO41241	UCEC	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	0.7133
p.P71L	TCGA-B5-A3FC	UCEC	TCGA	RRRILAGLL	DEG_APCC_DBOX_1	0.1667
p.P71L	DO41871	UCEC	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	0.1667
p.P71L	ACH-000994	Endometrial/Uterine Cancer	CCLE	RRRILAGLL	DEG_APCC_DBOX_1	0.1667
p.A67T	TCGA-EI-6507	READ	TCGA	RRRILAGLL	DEG_APCC_DBOX_1	0.2778
p.A67T	DO36675	READ	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	0.2778
p.P75H	DO233641	GACA	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	0.0556
p.A47T	DO233864	GACA	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	0.0556
p.M75I	DO37432	SKCM	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	0.0556
p.S59N	DO42344	UCEC	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	0.7069
p.V51I	DO41235	UCEC	ICGC	RRRILAGLL	DEG_APCC_DBOX_1	0.1667
p.P54S	SIDM00140	Melanoma	GDSC	RRRILAGLL	DEG_APCC_DBOX_1	0.25
p.P54S	ACH-000968	Skin Cancer	CCLE	RRRILAGLL	DEG_APCC_DBOX_1	0.25
p.A67V	SIDM00537	Colorectal Carcinoma	GDSC	RRRILAGLL	DEG_APCC_DBOX_1	0.2778
p.A67V	ACH-000982	Colon/Colorectal Cancer	CCLE	RRRILAGLL	DEG_APCC_DBOX_1	0.2778
p.A67V	ACH-001345	Colon/Colorectal Cancer	CCLE	RRRILAGLL	DEG_APCC_DBOX_1	0.2778
p.M51I	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	RRRILAGLL	DEG_APCC_DBOX_1	0.1667
p.M51I	ACH-000727	Lung Cancer	CCLE	RRRILAGLL	DEG_APCC_DBOX_1	0.1667
p.V60L	G-292_Clone_A141B1	bone	COSMIC	RRRILAGLL	DEG_APCC_DBOX_1	0.6765
p.R66Q	OCI-LY7	haematopoietic_and_lymphoid_tissue	COSMIC	RRRILAGLL	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96P48	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1	DEG_APCC_DBOX_1	57:65	RRRILAGLL	APC,CDC20,FZR1	0.9774	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRRILAGLL

Degron related mutations and impact score

Drug responses associated with ARAP1 mutations

All proteins holding degron of RRRILAGLL