DegronMD - Q96P53(WDFY2)

WDFY2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T386A	TCGA-AA-A010	COAD	TCGA	MTPVVS	DEG_SCF_FBW7_1	395:400	Mutation blocking phosphorylation signal	0.5278
p.W393L	TCGA-CR-5248	HNSC	TCGA	MTPVVS	DEG_SCF_FBW7_1	395:400	Mutation rewiring degron network	0.2778
p.W393L	DO14694	HNSC	ICGC	MTPVVS	DEG_SCF_FBW7_1	395:400	Mutation rewiring degron network	0.2778
p.V399M	TCGA-D1-A163	UCEC	TCGA	MTPVVS	DEG_SCF_FBW7_1	395:400	Mutation altering degron motif	0.6097
p.V399M	DO41008	UCEC	ICGC	MTPVVS	DEG_SCF_FBW7_1	395:400	Mutation altering degron motif	0.6097
p.P397Q	TCGA-EO-A3B0	UCEC	TCGA	MTPVVS	DEG_SCF_FBW7_1	395:400	Mutation altering degron motif	0.7035
p.P397Q	DO219773	UCEC	ICGC	MTPVVS	DEG_SCF_FBW7_1	395:400	Mutation altering degron motif	0.7035
p.V389G	TCGA-FS-A4F0	SKCM	TCGA	MTPVVS	DEG_SCF_FBW7_1	395:400	Mutation rewiring degron network	0.1667
p.V389G	DO37891	SKCM	ICGC	MTPVVS	DEG_SCF_FBW7_1	395:400	Mutation rewiring degron network	0.1667
p.T396A	SIDM01609	Endometrial Carcinoma	GDSC	MTPVVS	DEG_SCF_FBW7_1	395:400	Mutation altering degron motif	0.7139
p.T396A	ACH-000972	Endometrial/Uterine Cancer	CCLE	MTPVVS	DEG_SCF_FBW7_1	395:400	Mutation altering degron motif	0.7139
p.M395I	ACH-000555	Kidney Cancer	CCLE	MTPVVS	DEG_SCF_FBW7_1	395:400	Mutation altering degron motif	0.6507
p.K388E	ACH-001061	Colon/Colorectal Cancer	CCLE	MTPVVS	DEG_SCF_FBW7_1	395:400	Mutation substituting flanking lysine	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc