DegronMD

Uniprot ID: Q96P53

Source protein: WD repeat and FYVE domain-containing protein 2

Source gene: WDFY2

Class: DEG_SCF_FBW7_1

Location: 395:400

E3 ligase: FBXW7

DEGRON score: 0.9918

ASA_SCORE: 72.9333

COIL: 0.9138

CONS_SCORE: 0.4343

DSS_SCORE: 0.5678

HELIX: 0.0163

FCONS_SCORE: 0.7501

RIG_SCORE: 0.8601

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T386A	TCGA-AA-A010	COAD	TCGA	MTPVVS	DEG_SCF_FBW7_1	0.5278
p.W393L	TCGA-CR-5248	HNSC	TCGA	MTPVVS	DEG_SCF_FBW7_1	0.2778
p.W393L	DO14694	HNSC	ICGC	MTPVVS	DEG_SCF_FBW7_1	0.2778
p.V399M	TCGA-D1-A163	UCEC	TCGA	MTPVVS	DEG_SCF_FBW7_1	0.6097
p.V399M	DO41008	UCEC	ICGC	MTPVVS	DEG_SCF_FBW7_1	0.6097
p.P397Q	TCGA-EO-A3B0	UCEC	TCGA	MTPVVS	DEG_SCF_FBW7_1	0.7035
p.P397Q	DO219773	UCEC	ICGC	MTPVVS	DEG_SCF_FBW7_1	0.7035
p.V389G	TCGA-FS-A4F0	SKCM	TCGA	MTPVVS	DEG_SCF_FBW7_1	0.1667
p.V389G	DO37891	SKCM	ICGC	MTPVVS	DEG_SCF_FBW7_1	0.1667
p.T396A	SIDM01609	Endometrial Carcinoma	GDSC	MTPVVS	DEG_SCF_FBW7_1	0.7139
p.T396A	ACH-000972	Endometrial/Uterine Cancer	CCLE	MTPVVS	DEG_SCF_FBW7_1	0.7139
p.M395I	ACH-000555	Kidney Cancer	CCLE	MTPVVS	DEG_SCF_FBW7_1	0.6507
p.K388E	ACH-001061	Colon/Colorectal Cancer	CCLE	MTPVVS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96P53	WD repeat and FYVE domain-containing protein 2	DEG_SCF_FBW7_1	395:400	MTPVVS	FBXW7	0.9918	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons