NECAB3
UniProt ID: Q96P71
Entrez ID: 63941
Protein name: N-terminal EF-hand calcium-binding protein 3 (Amyloid-beta A4 protein-binding family A member 2-binding protein) (Nek2-interacting protein 1) (Neuronal calcium-binding protein 3) (X11L-binding protein 51)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the ...
FUNCTION: Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3. {ECO:0000269|PubMed:10833507, ECO:0000269|PubMed:26948053}.
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GO - Biological processes (BP):
protein metabolic process [GO:0019538]; protein secretion [GO:0009306]; regulation of amyloid precursor protein biosynthetic process [GO:0042984]...
protein metabolic process [GO:0019538]; protein secretion [GO:0009306]; regulation of amyloid precursor protein biosynthetic process [GO:0042984]
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GO - Molecular function (MF):
calcium ion binding [GO:0005509]...
calcium ion binding [GO:0005509]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; nucleus [GO:0005634]...
cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi cis cisterna [GO:0000137]; nucleus [GO:0005634]
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NECAB3
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*NOTE: the Kaplan plots were collected from OncoLnc