DegronMD

Uniprot ID: Q96P71

Source protein: N-terminal EF-hand calcium-binding protein 3

Source gene: NECAB3

Class: DEG_APCC_DBOX_1

Location: 194:202

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9077

ASA_SCORE: 92.3111

COIL: 0.6822

CONS_SCORE: 0.5069

DSS_SCORE: 0.5065

HELIX: 0.2377

FCONS_SCORE: 1.2939

RIG_SCORE: 0.6699

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R195L	DO229259	THCA	ICGC	GRRALRSVS	DEG_APCC_DBOX_1	0.8428
p.R195C	TCGA-G4-6309	COAD	TCGA	GRRALRSVS	DEG_APCC_DBOX_1	0.8301
p.R195C	DO7810	COAD	ICGC	GRRALRSVS	DEG_APCC_DBOX_1	0.8301
p.R203W	ACH-000218	Leukemia	CCLE	GRRALRSVS	DEG_APCC_DBOX_1	0.3056
p.R203W	ACH-000570	Brain Cancer	CCLE	GRRALRSVS	DEG_APCC_DBOX_1	0.3056
p.R203W	ACH-000577	Liver Cancer	CCLE	GRRALRSVS	DEG_APCC_DBOX_1	0.3056
p.R203W	ACH-000941	Endometrial/Uterine Cancer	CCLE	GRRALRSVS	DEG_APCC_DBOX_1	0.3056
p.R203W	ACH-000954	Endometrial/Uterine Cancer	CCLE	GRRALRSVS	DEG_APCC_DBOX_1	0.3056
p.R203W	ACH-001060	Lymphoma	CCLE	GRRALRSVS	DEG_APCC_DBOX_1	0.3056
p.R203W	ACH-001515	Cervical Cancer	CCLE	GRRALRSVS	DEG_APCC_DBOX_1	0.3056
p.R203W	ACH-001517	Endometrial/Uterine Cancer	CCLE	GRRALRSVS	DEG_APCC_DBOX_1	0.3056
p.R191W	SIDM00945	Colorectal Carcinoma	GDSC	GRRALRSVS	DEG_APCC_DBOX_1	0.25
p.S208F	TCGA-DX-A8BP	SARC	TCGA	GRRALRSVS	DEG_APCC_DBOX_1	0.1667
p.S208F	DO220056	SARC	ICGC	GRRALRSVS	DEG_APCC_DBOX_1	0.1667

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96P71	N-terminal EF-hand calcium-binding protein 3	DEG_APCC_DBOX_1	194:202	GRRALRSVS	APC,CDC20,FZR1	0.9077	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons