DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
GRRALRSVS
Uniprot ID:
Q96P71
Source protein:
N-terminal EF-hand calcium-binding protein 3
Source gene:
NECAB3
Class:
DEG_APCC_DBOX_1
Location:
194:202
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9077
ASA_SCORE:
92.3111
COIL:
0.6822
CONS_SCORE:
0.5069
DSS_SCORE:
0.5065
HELIX:
0.2377
FCONS_SCORE:
1.2939
RIG_SCORE:
0.6699
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S208F
TCGA-DX-A8BP
SARC
TCGA
GRRALRSVS
DEG_APCC_DBOX_1
0.1667
p.S208F
DO220056
SARC
ICGC
GRRALRSVS
DEG_APCC_DBOX_1
0.1667
p.R195C
TCGA-G4-6309
COAD
TCGA
GRRALRSVS
DEG_APCC_DBOX_1
0.8301
p.R195C
DO7810
COAD
ICGC
GRRALRSVS
DEG_APCC_DBOX_1
0.8301
p.R195L
DO229259
THCA
ICGC
GRRALRSVS
DEG_APCC_DBOX_1
0.8428
p.R191W
SIDM00945
Colorectal Carcinoma
GDSC
GRRALRSVS
DEG_APCC_DBOX_1
0.25
p.R203W
ACH-000218
Leukemia
CCLE
GRRALRSVS
DEG_APCC_DBOX_1
0.3056
p.R203W
ACH-000570
Brain Cancer
CCLE
GRRALRSVS
DEG_APCC_DBOX_1
0.3056
p.R203W
ACH-000577
Liver Cancer
CCLE
GRRALRSVS
DEG_APCC_DBOX_1
0.3056
p.R203W
ACH-000941
Endometrial/Uterine Cancer
CCLE
GRRALRSVS
DEG_APCC_DBOX_1
0.3056
p.R203W
ACH-000954
Endometrial/Uterine Cancer
CCLE
GRRALRSVS
DEG_APCC_DBOX_1
0.3056
p.R203W
ACH-001060
Lymphoma
CCLE
GRRALRSVS
DEG_APCC_DBOX_1
0.3056
p.R203W
ACH-001515
Cervical Cancer
CCLE
GRRALRSVS
DEG_APCC_DBOX_1
0.3056
p.R203W
ACH-001517
Endometrial/Uterine Cancer
CCLE
GRRALRSVS
DEG_APCC_DBOX_1
0.3056
Drug responses associated with NECAB3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of GRRALRSVS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96P71
N-terminal EF-hand calcium-binding protein 3
DEG_APCC_DBOX_1
194:202
GRRALRSVS
APC,CDC20,FZR1
0.9077
More...