DegronMD - Q96PC2(IP6K3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E147K	TCGA-66-2773	LUSC	TCGA	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.25
p.E147K	DO26536	LUSC	ICGC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.25
p.G163E	TCGA-EE-A29C	SKCM	TCGA	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.1389
p.G163E	TCGA-GN-A263	SKCM	TCGA	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.1389
p.G163E	DO222727	MELA	ICGC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.1389
p.G163E	DO37766	SKCM	ICGC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.1389
p.G163E	DO38028	SKCM	ICGC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.1389
p.T161I	TCGA-G6-A8L7	KIRC	TCGA	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.1944
p.T161I	DO50650	KIRC	ICGC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.1944
p.L150R	TCGA-HU-A4GN	STAD	TCGA	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation altering degron motif	0.8428
p.L150R	DO47833	STAD	ICGC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation altering degron motif	0.8428
p.Q165R	DO222427	BTCA	ICGC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.0833
p.G163R	DO218863	SKCA	ICGC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.1389
p.S156L	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation altering degron motif	0.7667
p.S156L	SIDM01113	Other Sarcomas	GDSC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation altering degron motif	0.7667
p.S156L	SIDM00391	Plasma Cell Myeloma	GDSC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation altering degron motif	0.7667
p.S156L	SIDM00806	Osteosarcoma	GDSC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation altering degron motif	0.7667
p.S156L	SIDM00151	Ovarian Carcinoma	GDSC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation altering degron motif	0.7667
p.S156L	SIDM00085	Glioma	GDSC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation altering degron motif	0.7667
p.S156L	SIDM01146	Gastric Carcinoma	GDSC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation altering degron motif	0.7667
p.R145M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.1944
p.L157M	SIDM00208	Glioblastoma	GDSC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.3056
p.L157M	ACH-002229	Brain Cancer	CCLE	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.3056
p.L157M	D-502MG	central nervous system	COSMIC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.3056
p.L143I	SIDM01611	Endometrial Carcinoma	GDSC	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.1389
p.L143I	ACH-000996	Endometrial/Uterine Cancer	CCLE	LNTPAFS	DEG_SCF_FBW7_1	150:156	Mutation rewiring degron network	0.1389

Kaplan plot for IP6K3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IP6K3

UniProt ID: Q96PC2

Entrez ID: 117283

Protein name: Inositol hexakisphosphate kinase 3 (InsP6 kinase 3) (EC 2.7.4.21) (Inositol hexaphosphate kinase 3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for IP6K3 in