DegronMD

Uniprot ID: Q96PC2

Source protein: Inositol hexakisphosphate kinase 3

Source gene: IP6K3

Class: DEG_SCF_FBW7_1

Location: 150:156

E3 ligase: FBXW7

DEGRON score: 0.881

ASA_SCORE: 59.0571

COIL: 0.7001

CONS_SCORE: 0.2186

DSS_SCORE: 0.5031

HELIX: 0.1473

FCONS_SCORE: 0.9298

RIG_SCORE: 0.7075

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E147K	TCGA-66-2773	LUSC	TCGA	LNTPAFS	DEG_SCF_FBW7_1	0.25
p.E147K	DO26536	LUSC	ICGC	LNTPAFS	DEG_SCF_FBW7_1	0.25
p.G163E	TCGA-EE-A29C	SKCM	TCGA	LNTPAFS	DEG_SCF_FBW7_1	0.1389
p.G163E	TCGA-GN-A263	SKCM	TCGA	LNTPAFS	DEG_SCF_FBW7_1	0.1389
p.G163E	DO222727	MELA	ICGC	LNTPAFS	DEG_SCF_FBW7_1	0.1389
p.G163E	DO37766	SKCM	ICGC	LNTPAFS	DEG_SCF_FBW7_1	0.1389
p.G163E	DO38028	SKCM	ICGC	LNTPAFS	DEG_SCF_FBW7_1	0.1389
p.T161I	TCGA-G6-A8L7	KIRC	TCGA	LNTPAFS	DEG_SCF_FBW7_1	0.1944
p.T161I	DO50650	KIRC	ICGC	LNTPAFS	DEG_SCF_FBW7_1	0.1944
p.L150R	TCGA-HU-A4GN	STAD	TCGA	LNTPAFS	DEG_SCF_FBW7_1	0.8428
p.L150R	DO47833	STAD	ICGC	LNTPAFS	DEG_SCF_FBW7_1	0.8428
p.Q165R	DO222427	BTCA	ICGC	LNTPAFS	DEG_SCF_FBW7_1	0.0833
p.G163R	DO218863	SKCA	ICGC	LNTPAFS	DEG_SCF_FBW7_1	0.1389
p.S156L	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	LNTPAFS	DEG_SCF_FBW7_1	0.7667
p.S156L	SIDM01113	Other Sarcomas	GDSC	LNTPAFS	DEG_SCF_FBW7_1	0.7667
p.S156L	SIDM00391	Plasma Cell Myeloma	GDSC	LNTPAFS	DEG_SCF_FBW7_1	0.7667
p.S156L	SIDM00806	Osteosarcoma	GDSC	LNTPAFS	DEG_SCF_FBW7_1	0.7667
p.S156L	SIDM00151	Ovarian Carcinoma	GDSC	LNTPAFS	DEG_SCF_FBW7_1	0.7667
p.S156L	SIDM00085	Glioma	GDSC	LNTPAFS	DEG_SCF_FBW7_1	0.7667
p.S156L	SIDM01146	Gastric Carcinoma	GDSC	LNTPAFS	DEG_SCF_FBW7_1	0.7667
p.R145M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	LNTPAFS	DEG_SCF_FBW7_1	0.1944
p.L157M	SIDM00208	Glioblastoma	GDSC	LNTPAFS	DEG_SCF_FBW7_1	0.3056
p.L157M	ACH-002229	Brain Cancer	CCLE	LNTPAFS	DEG_SCF_FBW7_1	0.3056
p.L157M	D-502MG	central_nervous_system	COSMIC	LNTPAFS	DEG_SCF_FBW7_1	0.3056
p.L143I	SIDM01611	Endometrial Carcinoma	GDSC	LNTPAFS	DEG_SCF_FBW7_1	0.1389
p.L143I	ACH-000996	Endometrial/Uterine Cancer	CCLE	LNTPAFS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PC2	Inositol hexakisphosphate kinase 3	DEG_SCF_FBW7_1	150:156	LNTPAFS	FBXW7	0.881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LNTPAFS

Degron related mutations and impact score

Drug responses associated with IP6K3 mutations

All proteins holding degron of LNTPAFS