DegronMD - Q96PX8(SLITRK1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P275H	TCGA-34-8455	LUSC	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.0556
p.P275H	DO50095	LUSC	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.0556
p.E296D	TCGA-57-1993	OV	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.2222
p.E296D	DO30910	OV	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.2222
p.P275R	TCGA-60-2720	LUSC	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.0556
p.P275R	DO26587	LUSC	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.0556
p.T288N	TCGA-69-7763	LUAD	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation altering degron motif	0.7055
p.T288N	DO24616	LUAD	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation altering degron motif	0.7055
p.Q277K	TCGA-75-5146	LUAD	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.1111
p.Q277K	DO25228	LUAD	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.1111
p.P289L	TCGA-86-7713	LUAD	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation altering degron motif	0.7582
p.P289L	TCGA-EE-A2GR	SKCM	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation altering degron motif	0.7582
p.P289L	DO24712	LUAD	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation altering degron motif	0.7582
p.P289L	DO37996	SKCM	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation altering degron motif	0.7582
p.P289T	TCGA-86-7713	LUAD	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation altering degron motif	0.7031
p.P289T	TCGA-ND-A4WC	UCS	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation altering degron motif	0.7031
p.P289T	DO234263	ESAD	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation altering degron motif	0.7031
p.P289T	DO24712	LUAD	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation altering degron motif	0.7031
p.T288A	TCGA-AA-3811	COAD	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation altering degron motif	0.7139
p.T288A	DO7962	COAD	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation altering degron motif	0.7139
p.P289H	TCGA-AA-A010	COAD	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation altering degron motif	0.7694
p.P289H	DO233732	GACA	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation altering degron motif	0.7694
p.P283H	TCGA-AP-A059	UCEC	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.2778
p.P283H	DO41361	UCEC	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.2778
p.A276S	TCGA-EL-A4KI	THCA	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.0833
p.A276S	DO39452	THCA	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.0833
p.Q295H	TCGA-EO-A22R	UCEC	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.25
p.Q295H	DO42713	UCEC	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.25
p.H298Y	TCGA-FW-A3R5	SKCM	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.1667
p.H298Y	DO37406	SKCM	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.1667
p.H298Y	SIDM01569	Hepatocellular Carcinoma	GDSC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.1667
p.H298Y	ACH-000734	Liver Cancer	CCLE	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.1667
p.D297N	TCGA-GN-A262	SKCM	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.1944
p.D297N	DO219873	SKCA	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.1944
p.D297N	DO37515	SKCM	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.1944
p.L286M	DO223052	ESCA	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation altering degron motif	0.5999
p.G302R	DO233842	GACA	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.0556
p.A282D	DO229041	LICA	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.25
p.T292A	DO48728	LIRI	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation altering degron motif	0.7139
p.A282T	DO231033	LUSC	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.25
p.F281L	SIDM01171	Glioblastoma	GDSC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.2222
p.F281L	ACH-000571	Brain Cancer	CCLE	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.2222
p.F281L	T98G	central nervous system	COSMIC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.2222
p.P283S	SIDM00284	Melanoma	GDSC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.2778
p.P283S	ACH-000805	Skin Cancer	CCLE	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.2778
p.P283S	COLO-679	skin	COSMIC	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.2778
p.N293T	ACH-000419	Myeloma	CCLE	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.3056
p.N293T	ACH-001541	Myeloma	CCLE	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.3056
p.G294V	ACH-001857	Bile Duct Cancer	CCLE	PLPTPFKT	DEG_SCF_FBW7_1	285:292	Mutation rewiring degron network	0.2778

Kaplan plot for SLITRK1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLITRK1

UniProt ID: Q96PX8

Entrez ID: 114798

Protein name: SLIT and NTRK-like protein 1 (Leucine-rich repeat-containing protein 12)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SLITRK1 in