DegronMD

Uniprot ID: Q96PX8

Source protein: SLIT and NTRK-like protein 1

Source gene: SLITRK1

Class: DEG_SCF_FBW7_1

Location: 285:292

E3 ligase: FBXW7

DEGRON score: 0.9889

ASA_SCORE: 46.7

COIL: 0.7886

CONS_SCORE: 0.6058

DSS_SCORE: 0.7827

HELIX: 0.0405

FCONS_SCORE: 1.0889

RIG_SCORE: 0.6194

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P275H	TCGA-34-8455	LUSC	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	0.0556
p.P275H	DO50095	LUSC	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.0556
p.E296D	TCGA-57-1993	OV	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	0.2222
p.E296D	DO30910	OV	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.2222
p.P275R	TCGA-60-2720	LUSC	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	0.0556
p.P275R	DO26587	LUSC	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.0556
p.T288N	TCGA-69-7763	LUAD	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	0.7055
p.T288N	DO24616	LUAD	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.7055
p.Q277K	TCGA-75-5146	LUAD	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	0.1111
p.Q277K	DO25228	LUAD	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.1111
p.P289L	TCGA-86-7713	LUAD	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	0.7582
p.P289L	TCGA-EE-A2GR	SKCM	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	0.7582
p.P289L	DO24712	LUAD	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.7582
p.P289L	DO37996	SKCM	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.7582
p.P289T	TCGA-86-7713	LUAD	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	0.7031
p.P289T	TCGA-ND-A4WC	UCS	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	0.7031
p.P289T	DO234263	ESAD	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.7031
p.P289T	DO24712	LUAD	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.7031
p.T288A	TCGA-AA-3811	COAD	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	0.7139
p.T288A	DO7962	COAD	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.7139
p.P289H	TCGA-AA-A010	COAD	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	0.7694
p.P289H	DO233732	GACA	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.7694
p.P283H	TCGA-AP-A059	UCEC	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	0.2778
p.P283H	DO41361	UCEC	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.2778
p.A276S	TCGA-EL-A4KI	THCA	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	0.0833
p.A276S	DO39452	THCA	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.0833
p.Q295H	TCGA-EO-A22R	UCEC	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	0.25
p.Q295H	DO42713	UCEC	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.25
p.H298Y	TCGA-FW-A3R5	SKCM	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	0.1667
p.H298Y	DO37406	SKCM	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.1667
p.H298Y	SIDM01569	Hepatocellular Carcinoma	GDSC	PLPTPFKT	DEG_SCF_FBW7_1	0.1667
p.H298Y	ACH-000734	Liver Cancer	CCLE	PLPTPFKT	DEG_SCF_FBW7_1	0.1667
p.D297N	TCGA-GN-A262	SKCM	TCGA	PLPTPFKT	DEG_SCF_FBW7_1	0.1944
p.D297N	DO219873	SKCA	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.1944
p.D297N	DO37515	SKCM	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.1944
p.L286M	DO223052	ESCA	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.5999
p.G302R	DO233842	GACA	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.0556
p.A282D	DO229041	LICA	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.25
p.T292A	DO48728	LIRI	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.7139
p.A282T	DO231033	LUSC	ICGC	PLPTPFKT	DEG_SCF_FBW7_1	0.25
p.F281L	SIDM01171	Glioblastoma	GDSC	PLPTPFKT	DEG_SCF_FBW7_1	0.2222
p.F281L	ACH-000571	Brain Cancer	CCLE	PLPTPFKT	DEG_SCF_FBW7_1	0.2222
p.F281L	T98G	central_nervous_system	COSMIC	PLPTPFKT	DEG_SCF_FBW7_1	0.2222
p.P283S	SIDM00284	Melanoma	GDSC	PLPTPFKT	DEG_SCF_FBW7_1	0.2778
p.P283S	ACH-000805	Skin Cancer	CCLE	PLPTPFKT	DEG_SCF_FBW7_1	0.2778
p.P283S	COLO-679	skin	COSMIC	PLPTPFKT	DEG_SCF_FBW7_1	0.2778
p.N293T	ACH-000419	Myeloma	CCLE	PLPTPFKT	DEG_SCF_FBW7_1	0.3056
p.N293T	ACH-001541	Myeloma	CCLE	PLPTPFKT	DEG_SCF_FBW7_1	0.3056
p.G294V	ACH-001857	Bile Duct Cancer	CCLE	PLPTPFKT	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLPTPFKT

Degron related mutations and impact score

Drug responses associated with SLITRK1 mutations

All proteins holding degron of PLPTPFKT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PX8	SLIT and NTRK-like protein 1	DEG_SCF_FBW7_1	285:292	PLPTPFKT	FBXW7	0.9889	More...