DegronMD - Q96PZ2(FAM111A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E269Q	TCGA-55-A4DF	LUAD	TCGA	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation altering degron motif	0.6744
p.E269Q	DO45318	LUAD	ICGC	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation altering degron motif	0.6744
p.S275N	TCGA-AP-A059	UCEC	TCGA	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation altering degron motif	0.7069
p.S275N	DO41361	UCEC	ICGC	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation altering degron motif	0.7069
p.P282L	TCGA-CD-A48A	STAD	TCGA	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation rewiring degron network	0.1667
p.P282L	DO47781	STAD	ICGC	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation rewiring degron network	0.1667
p.R271K	TCGA-D5-6538	COAD	TCGA	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation altering degron motif	0.6126
p.R271K	DO7784	COAD	ICGC	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation altering degron motif	0.6126
p.R271T	TCGA-K4-A54R	BLCA	TCGA	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation altering degron motif	0.6765
p.R271T	DO48611	BLCA	ICGC	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation altering degron motif	0.6765
p.F264L	SIDM01119	Other Solid Cancers	GDSC	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation rewiring degron network	0.25
p.F264L	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation rewiring degron network	0.25
p.F264L	SIDM00839	Colorectal Carcinoma	GDSC	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation rewiring degron network	0.25
p.E267Q	SIDM00594	Acute Myeloid Leukemia	GDSC	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation altering degron motif	0.6744
p.E267Q	ACH-000004	Leukemia	CCLE	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation altering degron motif	0.6744
p.E267Q	ACH-000005	Leukemia	CCLE	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation altering degron motif	0.6744
p.E267Q	HEL	haematopoietic and lymphoid tissue	COSMIC	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation altering degron motif	0.6744
p.E267Q	CMK	haematopoietic and lymphoid tissue	COSMIC	EVEKRMVPSA	DEG_COP1_1	267:276	Mutation altering degron motif	0.6744

Kaplan plot for FAM111A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM111A

UniProt ID: Q96PZ2

Entrez ID: 63901

Protein name: Serine protease FAM111A (EC 3.4.21.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM111A in