DegronMD

Uniprot ID: Q96PZ2

Source protein: Serine protease FAM111A

Source gene: FAM111A

Class: DEG_COP1_1

Location: 267:276

E3 ligase: COP1

DEGRON score: 0.7245

ASA_SCORE: 82.21

COIL: 0.5177

CONS_SCORE: 0.5044

DSS_SCORE: 0.4352

HELIX: 0.0538

FCONS_SCORE: 0.8378

RIG_SCORE: 0.7731

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E269Q	TCGA-55-A4DF	LUAD	TCGA	EVEKRMVPSA	DEG_COP1_1	0.6744
p.E269Q	DO45318	LUAD	ICGC	EVEKRMVPSA	DEG_COP1_1	0.6744
p.S275N	TCGA-AP-A059	UCEC	TCGA	EVEKRMVPSA	DEG_COP1_1	0.7069
p.S275N	DO41361	UCEC	ICGC	EVEKRMVPSA	DEG_COP1_1	0.7069
p.P282L	TCGA-CD-A48A	STAD	TCGA	EVEKRMVPSA	DEG_COP1_1	0.1667
p.P282L	DO47781	STAD	ICGC	EVEKRMVPSA	DEG_COP1_1	0.1667
p.R271K	TCGA-D5-6538	COAD	TCGA	EVEKRMVPSA	DEG_COP1_1	0.6126
p.R271K	DO7784	COAD	ICGC	EVEKRMVPSA	DEG_COP1_1	0.6126
p.R271T	TCGA-K4-A54R	BLCA	TCGA	EVEKRMVPSA	DEG_COP1_1	0.6765
p.R271T	DO48611	BLCA	ICGC	EVEKRMVPSA	DEG_COP1_1	0.6765
p.F264L	SIDM01119	Other Solid Cancers	GDSC	EVEKRMVPSA	DEG_COP1_1	0.25
p.F264L	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	EVEKRMVPSA	DEG_COP1_1	0.25
p.F264L	SIDM00839	Colorectal Carcinoma	GDSC	EVEKRMVPSA	DEG_COP1_1	0.25
p.E267Q	SIDM00594	Acute Myeloid Leukemia	GDSC	EVEKRMVPSA	DEG_COP1_1	0.6744
p.E267Q	ACH-000004	Leukemia	CCLE	EVEKRMVPSA	DEG_COP1_1	0.6744
p.E267Q	ACH-000005	Leukemia	CCLE	EVEKRMVPSA	DEG_COP1_1	0.6744
p.E267Q	HEL	haematopoietic_and_lymphoid_tissue	COSMIC	EVEKRMVPSA	DEG_COP1_1	0.6744
p.E267Q	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	EVEKRMVPSA	DEG_COP1_1	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PZ2	Serine protease FAM111A	DEG_COP1_1	267:276	EVEKRMVPSA	COP1	0.7245	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons