DegronMD - Q96PZ7(CSMD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T867K	TCGA-61-2018	OV	TCGA	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.25
p.T867K	DO29218	OV	ICGC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.25
p.R854C	TCGA-AX-A06F	UCEC	TCGA	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1944
p.R854C	TCGA-Y8-A894	KIRP	TCGA	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1944
p.R854C	DO233078	GACA	ICGC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1944
p.R854C	DO49798	KIRP	ICGC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1944
p.R854C	DO41752	UCEC	ICGC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1944
p.D851G	TCGA-F5-6814	READ	TCGA	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1111
p.D851G	DO36556	READ	ICGC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1111
p.S872F	TCGA-FR-A726	SKCM	TCGA	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1111
p.S872F	DO222536	MELA	ICGC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1111
p.S872F	DO48665	SKCM	ICGC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1111
p.T867A	DO222737	COCA	ICGC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.25
p.T867M	DO233160	GACA	ICGC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.25
p.S856G	DO233791	GACA	ICGC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.25
p.S853R	DO229035	LICA	ICGC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1667
p.S856R	DO229009	LICA	ICGC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.25
p.R854H	DO23132	LINC	ICGC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1944
p.D851V	DO220864	MELA	ICGC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1111
p.D851V	FU-OV-1	ovary	COSMIC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1111
p.S870L	DO46513	OV	ICGC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1667
p.D851E	SIDM00791	Chronic Myelogenous Leukemia	GDSC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1111
p.D851E	K-562	haematopoietic and lymphoid tissue	COSMIC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1111
p.V866L	SIDM00280	Gastric Carcinoma	GDSC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.2778
p.V866L	ECC10	stomach	COSMIC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.2778
p.G858C	SIDM00312	Plasma Cell Myeloma	GDSC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.3056
p.G858C	L-363	haematopoietic and lymphoid tissue	COSMIC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.3056
p.S865N	SIDM00150	Colorectal Carcinoma	GDSC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.3056
p.S865N	KM12	large intestine	COSMIC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.3056
p.G859C	ACH-000183	Myeloma	CCLE	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation altering degron motif	0.76
p.G859C	L-363	haematopoietic and lymphoid tissue	COSMIC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation altering degron motif	0.76
p.V867L	ACH-000560	Gastric Cancer	CCLE	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.25
p.V867L	ECC10	stomach	COSMIC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.25
p.D852E	ACH-002061	Leukemia	CCLE	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1389
p.D852E	K-562	haematopoietic and lymphoid tissue	COSMIC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.1389
p.G863W	NCI-H2110	lung	COSMIC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation altering degron motif	0.7825
p.S866N	KM12	large intestine	COSMIC	FLIHYE	LIG_APCC_ABBA_1	859:864	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CSMD1

UniProt ID: Q96PZ7

Entrez ID: 64478

Protein name: CUB and sushi domain-containing protein 1 (CUB and sushi multiple domains protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CSMD1 in