DegronMD

Uniprot ID: Q96PZ7

Source protein: CUB and sushi domain-containing protein 1

Source gene: CSMD1

Class: LIG_APCC_ABBA_1

Location: 859:864

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8826

ASA_SCORE: 84.5833

COIL: 0.5865

CONS_SCORE: 0.5657

DSS_SCORE: 0.1398

HELIX: 0.0207

FCONS_SCORE: 1.3146

RIG_SCORE: 0.8748

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T867K	TCGA-61-2018	OV	TCGA	FLIHYE	LIG_APCC_ABBA_1	0.25
p.T867K	DO29218	OV	ICGC	FLIHYE	LIG_APCC_ABBA_1	0.25
p.R854C	TCGA-AX-A06F	UCEC	TCGA	FLIHYE	LIG_APCC_ABBA_1	0.1944
p.R854C	TCGA-Y8-A894	KIRP	TCGA	FLIHYE	LIG_APCC_ABBA_1	0.1944
p.R854C	DO233078	GACA	ICGC	FLIHYE	LIG_APCC_ABBA_1	0.1944
p.R854C	DO49798	KIRP	ICGC	FLIHYE	LIG_APCC_ABBA_1	0.1944
p.R854C	DO41752	UCEC	ICGC	FLIHYE	LIG_APCC_ABBA_1	0.1944
p.D851G	TCGA-F5-6814	READ	TCGA	FLIHYE	LIG_APCC_ABBA_1	0.1111
p.D851G	DO36556	READ	ICGC	FLIHYE	LIG_APCC_ABBA_1	0.1111
p.S872F	TCGA-FR-A726	SKCM	TCGA	FLIHYE	LIG_APCC_ABBA_1	0.1111
p.S872F	DO222536	MELA	ICGC	FLIHYE	LIG_APCC_ABBA_1	0.1111
p.S872F	DO48665	SKCM	ICGC	FLIHYE	LIG_APCC_ABBA_1	0.1111
p.T867A	DO222737	COCA	ICGC	FLIHYE	LIG_APCC_ABBA_1	0.25
p.T867M	DO233160	GACA	ICGC	FLIHYE	LIG_APCC_ABBA_1	0.25
p.S856G	DO233791	GACA	ICGC	FLIHYE	LIG_APCC_ABBA_1	0.25
p.S853R	DO229035	LICA	ICGC	FLIHYE	LIG_APCC_ABBA_1	0.1667
p.S856R	DO229009	LICA	ICGC	FLIHYE	LIG_APCC_ABBA_1	0.25
p.R854H	DO23132	LINC	ICGC	FLIHYE	LIG_APCC_ABBA_1	0.1944
p.D851V	DO220864	MELA	ICGC	FLIHYE	LIG_APCC_ABBA_1	0.1111
p.D851V	FU-OV-1	ovary	COSMIC	FLIHYE	LIG_APCC_ABBA_1	0.1111
p.S870L	DO46513	OV	ICGC	FLIHYE	LIG_APCC_ABBA_1	0.1667
p.D851E	SIDM00791	Chronic Myelogenous Leukemia	GDSC	FLIHYE	LIG_APCC_ABBA_1	0.1111
p.D851E	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	FLIHYE	LIG_APCC_ABBA_1	0.1111
p.V866L	SIDM00280	Gastric Carcinoma	GDSC	FLIHYE	LIG_APCC_ABBA_1	0.2778
p.V866L	ECC10	stomach	COSMIC	FLIHYE	LIG_APCC_ABBA_1	0.2778
p.G858C	SIDM00312	Plasma Cell Myeloma	GDSC	FLIHYE	LIG_APCC_ABBA_1	0.3056
p.G858C	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	FLIHYE	LIG_APCC_ABBA_1	0.3056
p.S865N	SIDM00150	Colorectal Carcinoma	GDSC	FLIHYE	LIG_APCC_ABBA_1	0.3056
p.S865N	KM12	large_intestine	COSMIC	FLIHYE	LIG_APCC_ABBA_1	0.3056
p.G859C	ACH-000183	Myeloma	CCLE	FLIHYE	LIG_APCC_ABBA_1	0.76
p.G859C	L-363	haematopoietic_and_lymphoid_tissue	COSMIC	FLIHYE	LIG_APCC_ABBA_1	0.76
p.V867L	ACH-000560	Gastric Cancer	CCLE	FLIHYE	LIG_APCC_ABBA_1	0.25
p.V867L	ECC10	stomach	COSMIC	FLIHYE	LIG_APCC_ABBA_1	0.25
p.D852E	ACH-002061	Leukemia	CCLE	FLIHYE	LIG_APCC_ABBA_1	0.1389
p.D852E	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	FLIHYE	LIG_APCC_ABBA_1	0.1389
p.G863W	NCI-H2110	lung	COSMIC	FLIHYE	LIG_APCC_ABBA_1	0.7825
p.S866N	KM12	large_intestine	COSMIC	FLIHYE	LIG_APCC_ABBA_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FLIHYE

Degron related mutations and impact score

Drug responses associated with CSMD1 mutations

All proteins holding degron of FLIHYE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PZ7	CUB and sushi domain-containing protein 1	LIG_APCC_ABBA_1	859:864	FLIHYE	APC,CDC20,FZR1	0.8826	More...