DegronMD - Q96Q06(PLIN4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1291E	TCGA-67-4679	LUAD	TCGA	ARHSLCELY	DEG_APCC_DBOX_1	1291:1299	Mutation altering degron motif	0.659
p.A1291E	DO23604	LUAD	ICGC	ARHSLCELY	DEG_APCC_DBOX_1	1291:1299	Mutation altering degron motif	0.659
p.S1294N	TCGA-FI-A2D5	UCEC	TCGA	ARHSLCELY	DEG_APCC_DBOX_1	1291:1299	Mutation altering degron motif	0.5958
p.S1294N	DO41331	UCEC	ICGC	ARHSLCELY	DEG_APCC_DBOX_1	1291:1299	Mutation altering degron motif	0.5958
p.A1291V	DO50090	COAD	ICGC	ARHSLCELY	DEG_APCC_DBOX_1	1291:1299	Mutation altering degron motif	0.5825
p.S1307F	ACH-000778	Head and Neck Cancer	CCLE	ARHSLCELY	DEG_APCC_DBOX_1	1291:1299	Mutation rewiring degron network	0.1111
p.S1307F	HSC-3	upper aerodigestive tract	COSMIC	ARHSLCELY	DEG_APCC_DBOX_1	1291:1299	Mutation rewiring degron network	0.1111
p.S1304L	ACH-000778	Head and Neck Cancer	CCLE	ARHSLCELY	DEG_APCC_DBOX_1	1291:1299	Mutation rewiring degron network	0.1944
p.S1304L	HSC-3	upper aerodigestive tract	COSMIC	ARHSLCELY	DEG_APCC_DBOX_1	1291:1299	Mutation rewiring degron network	0.1944
p.V1288L	ACH-000994	Endometrial/Uterine Cancer	CCLE	ARHSLCELY	DEG_APCC_DBOX_1	1291:1299	Mutation rewiring degron network	0.25
p.T1283M	EFO-27	ovary	COSMIC	ARHSLCELY	DEG_APCC_DBOX_1	1291:1299	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons