DegronMD

Uniprot ID: Q96Q06

Source protein: Perilipin-4

Source gene: PLIN4

Class: DEG_APCC_DBOX_1

Location: 1291:1299

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5112

ASA_SCORE: 48.6333

COIL: 0.0783

CONS_SCORE: 0.4616

DSS_SCORE: 0.1675

HELIX: 0.916

FCONS_SCORE: 1.2406

RIG_SCORE: 0.8091

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1291E	TCGA-67-4679	LUAD	TCGA	ARHSLCELY	DEG_APCC_DBOX_1	0.659
p.A1291E	DO23604	LUAD	ICGC	ARHSLCELY	DEG_APCC_DBOX_1	0.659
p.S1294N	TCGA-FI-A2D5	UCEC	TCGA	ARHSLCELY	DEG_APCC_DBOX_1	0.5958
p.S1294N	DO41331	UCEC	ICGC	ARHSLCELY	DEG_APCC_DBOX_1	0.5958
p.A1291V	DO50090	COAD	ICGC	ARHSLCELY	DEG_APCC_DBOX_1	0.5825
p.S1307F	ACH-000778	Head and Neck Cancer	CCLE	ARHSLCELY	DEG_APCC_DBOX_1	0.1111
p.S1307F	HSC-3	upper_aerodigestive_tract	COSMIC	ARHSLCELY	DEG_APCC_DBOX_1	0.1111
p.S1304L	ACH-000778	Head and Neck Cancer	CCLE	ARHSLCELY	DEG_APCC_DBOX_1	0.1944
p.S1304L	HSC-3	upper_aerodigestive_tract	COSMIC	ARHSLCELY	DEG_APCC_DBOX_1	0.1944
p.V1288L	ACH-000994	Endometrial/Uterine Cancer	CCLE	ARHSLCELY	DEG_APCC_DBOX_1	0.25
p.T1283M	EFO-27	ovary	COSMIC	ARHSLCELY	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96Q06	Perilipin-4	DEG_APCC_DBOX_1	1291:1299	ARHSLCELY	APC,CDC20,FZR1	0.5112	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons