DegronMD - Q96Q15(SMG1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D2965N	TCGA-AX-A2HC	UCEC	TCGA	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.0556
p.D2965N	TCGA-E6-A1LX	UCEC	TCGA	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.0556
p.D2965N	DO41020	UCEC	ICGC	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.0556
p.D2965N	DO41572	UCEC	ICGC	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.0556
p.A2963E	TCGA-BQ-5885	KIRP	TCGA	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.1111
p.A2963E	DO20921	KIRP	ICGC	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.1111
p.A2963T	TCGA-BQ-5885	KIRP	TCGA	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.1111
p.A2963T	DO20921	KIRP	ICGC	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.1111
p.R2944I	TCGA-BR-8680	STAD	TCGA	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.2222
p.R2944I	DO47769	STAD	ICGC	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.2222
p.P2943L	TCGA-D3-A2JF	SKCM	TCGA	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.1944
p.P2943L	DO38153	SKCM	ICGC	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.1944
p.L2940S	TCGA-DI-A1BU	UCEC	TCGA	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.1111
p.L2940S	DO42023	UCEC	ICGC	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.1111
p.I2941M	DO50668	ORCA	ICGC	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.1389
p.Q2942L	DO46372	OV	ICGC	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.1667
p.Q2942H	SIDM01612	Endometrial Carcinoma	GDSC	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.1667
p.Q2942H	ACH-000946	Endometrial/Uterine Cancer	CCLE	VDETPKMS	DEG_SCF_FBW7_1	2948:2955	Mutation rewiring degron network	0.1667

Kaplan plot for SMG1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMG1

UniProt ID: Q96Q15

Entrez ID: 23049

Protein name: Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMG1 in