DegronMD

Uniprot ID: Q96Q15

Source protein: Serine/threonine-protein kinase SMG1

Source gene: SMG1

Class: DEG_SCF_FBW7_1

Location: 2948:2955

E3 ligase: FBXW7

DEGRON score: 0.6788

ASA_SCORE: 81.7

COIL: 0.8375

CONS_SCORE: 0.2608

DSS_SCORE: 0.3949

HELIX: 0.1293

FCONS_SCORE: 0.7843

RIG_SCORE: 0.7445

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2965N	TCGA-AX-A2HC	UCEC	TCGA	VDETPKMS	DEG_SCF_FBW7_1	0.0556
p.D2965N	TCGA-E6-A1LX	UCEC	TCGA	VDETPKMS	DEG_SCF_FBW7_1	0.0556
p.D2965N	DO41020	UCEC	ICGC	VDETPKMS	DEG_SCF_FBW7_1	0.0556
p.D2965N	DO41572	UCEC	ICGC	VDETPKMS	DEG_SCF_FBW7_1	0.0556
p.A2963E	TCGA-BQ-5885	KIRP	TCGA	VDETPKMS	DEG_SCF_FBW7_1	0.1111
p.A2963E	DO20921	KIRP	ICGC	VDETPKMS	DEG_SCF_FBW7_1	0.1111
p.A2963T	TCGA-BQ-5885	KIRP	TCGA	VDETPKMS	DEG_SCF_FBW7_1	0.1111
p.A2963T	DO20921	KIRP	ICGC	VDETPKMS	DEG_SCF_FBW7_1	0.1111
p.R2944I	TCGA-BR-8680	STAD	TCGA	VDETPKMS	DEG_SCF_FBW7_1	0.2222
p.R2944I	DO47769	STAD	ICGC	VDETPKMS	DEG_SCF_FBW7_1	0.2222
p.P2943L	TCGA-D3-A2JF	SKCM	TCGA	VDETPKMS	DEG_SCF_FBW7_1	0.1944
p.P2943L	DO38153	SKCM	ICGC	VDETPKMS	DEG_SCF_FBW7_1	0.1944
p.L2940S	TCGA-DI-A1BU	UCEC	TCGA	VDETPKMS	DEG_SCF_FBW7_1	0.1111
p.L2940S	DO42023	UCEC	ICGC	VDETPKMS	DEG_SCF_FBW7_1	0.1111
p.I2941M	DO50668	ORCA	ICGC	VDETPKMS	DEG_SCF_FBW7_1	0.1389
p.Q2942L	DO46372	OV	ICGC	VDETPKMS	DEG_SCF_FBW7_1	0.1667
p.Q2942H	SIDM01612	Endometrial Carcinoma	GDSC	VDETPKMS	DEG_SCF_FBW7_1	0.1667
p.Q2942H	ACH-000946	Endometrial/Uterine Cancer	CCLE	VDETPKMS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96Q15	Serine/threonine-protein kinase SMG1	DEG_SCF_FBW7_1	2948:2955	VDETPKMS	FBXW7	0.6788	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons