DegronMD - Q96QD5(DEPDC7)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E147D	TCGA-AP-A056	UCEC	TCGA	GKENK	DEG_APCC_KENBOX_2	145:149	Mutation altering degron motif	0.6758
p.E147D	TCGA-QS-A5YQ	UCEC	TCGA	GKENK	DEG_APCC_KENBOX_2	145:149	Mutation altering degron motif	0.6758
p.D156N	DO1697	BRCA	ICGC	GKENK	DEG_APCC_KENBOX_2	145:149	Mutation blocking phosphorylation signal	0.5833
p.E138D	DO49073	UCEC	ICGC	GKENK	DEG_APCC_KENBOX_2	145:149	Mutation rewiring degron network	0.1389
p.E138D	DO43971	UCEC	ICGC	GKENK	DEG_APCC_KENBOX_2	145:149	Mutation rewiring degron network	0.1389
p.Q143H	ACH-000659	Lung Cancer	CCLE	GKENK	DEG_APCC_KENBOX_2	145:149	Mutation rewiring degron network	0.2778
p.Q143H	ACH-001386	Lung Cancer	CCLE	GKENK	DEG_APCC_KENBOX_2	145:149	Mutation rewiring degron network	0.2778
p.R158I	COLO-668	lung	COSMIC	GKENK	DEG_APCC_KENBOX_2	145:149	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons