DegronMD

Uniprot ID: Q96QD5

Source protein: DEP domain-containing protein 7

Source gene: DEPDC7

Class: DEG_APCC_KENBOX_2

Location: 145:149

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7832

ASA_SCORE: 102.52

COIL: 0.7178

CONS_SCORE: 0.4608

DSS_SCORE: 0.446

HELIX: 0.1958

FCONS_SCORE: 1.1095

RIG_SCORE: 0.7513

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E147D	TCGA-AP-A056	UCEC	TCGA	GKENK	DEG_APCC_KENBOX_2	0.6758
p.E147D	TCGA-QS-A5YQ	UCEC	TCGA	GKENK	DEG_APCC_KENBOX_2	0.6758
p.D156N	DO1697	BRCA	ICGC	GKENK	DEG_APCC_KENBOX_2	0.5833
p.E138D	DO49073	UCEC	ICGC	GKENK	DEG_APCC_KENBOX_2	0.1389
p.E138D	DO43971	UCEC	ICGC	GKENK	DEG_APCC_KENBOX_2	0.1389
p.Q143H	ACH-000659	Lung Cancer	CCLE	GKENK	DEG_APCC_KENBOX_2	0.2778
p.Q143H	ACH-001386	Lung Cancer	CCLE	GKENK	DEG_APCC_KENBOX_2	0.2778
p.R158I	COLO-668	lung	COSMIC	GKENK	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11142	Heat shock cognate 71 kDa protein	DEG_APCC_KENBOX_2	496:500	GKENK	APC,CDC20,FZR1	0.8507	More...
P54652	Heat shock-related 70 kDa protein 2	DEG_APCC_KENBOX_2	499:503	GKENK	APC,CDC20,FZR1	0.7207	More...
Q96QD5	DEP domain-containing protein 7	DEG_APCC_KENBOX_2	145:149	GKENK	APC,CDC20,FZR1	0.7832	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons