DegronMD

Uniprot ID: P11142

Source protein: Heat shock cognate 71 kDa protein

Source gene: HSPA8

Class: DEG_APCC_KENBOX_2

Location: 496:500

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8507

ASA_SCORE: 87.44

COIL: 0.3842

CONS_SCORE: 0.7826

DSS_SCORE: 0.4185

HELIX: 0.0034

FCONS_SCORE: 0.8974

RIG_SCORE: 0.7265

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L486P	TCGA-BP-5195	KIRC	TCGA	GKENK	DEG_APCC_KENBOX_2	0.0556
p.L486P	DO18026	KIRC	ICGC	GKENK	DEG_APCC_KENBOX_2	0.0556
p.N487S	TCGA-DK-AA74	BLCA	TCGA	GKENK	DEG_APCC_KENBOX_2	0.0833
p.N487S	TCGA-ZG-A9N3	PRAD	TCGA	GKENK	DEG_APCC_KENBOX_2	0.0833
p.N487S	DO219011	BLCA	ICGC	GKENK	DEG_APCC_KENBOX_2	0.0833
p.N487S	DO219446	PRAD	ICGC	GKENK	DEG_APCC_KENBOX_2	0.0833
p.E498D	TCGA-IN-A6RP	STAD	TCGA	GKENK	DEG_APCC_KENBOX_2	0.6758
p.E498D	DO51741	STAD	ICGC	GKENK	DEG_APCC_KENBOX_2	0.6758
p.V491L	TCGA-OR-A5KB	ACC	TCGA	GKENK	DEG_APCC_KENBOX_2	0.1944
p.T504N	DO229019	LICA	ICGC	GKENK	DEG_APCC_KENBOX_2	0.2222
p.T495K	DO217836	ORCA	ICGC	GKENK	DEG_APCC_KENBOX_2	0.3056
p.L510V	DO231344	THCA	ICGC	GKENK	DEG_APCC_KENBOX_2	0.0556
p.I501T	SIDM00220	Ovarian Carcinoma	GDSC	GKENK	DEG_APCC_KENBOX_2	0.3056
p.I501T	ACH-000962	Ovarian Cancer	CCLE	GKENK	DEG_APCC_KENBOX_2	0.3056
p.I501T	ACH-001145	Ovarian Cancer	CCLE	GKENK	DEG_APCC_KENBOX_2	0.3056
p.I501T	OC-314	ovary	COSMIC	GKENK	DEG_APCC_KENBOX_2	0.3056
p.N505D	SIDM01608	Endometrial Carcinoma	GDSC	GKENK	DEG_APCC_KENBOX_2	0.1944
p.N505D	ACH-000990	Endometrial/Uterine Cancer	CCLE	GKENK	DEG_APCC_KENBOX_2	0.1944
p.E497K	SW900	lung	COSMIC	GKENK	DEG_APCC_KENBOX_2	0.7022
p.E491Q	HDQ-P1	breast	COSMIC	GKENK	DEG_APCC_KENBOX_2	0.1944
p.E490K	SW900	lung	COSMIC	GKENK	DEG_APCC_KENBOX_2	0.1667
p.E490V	NCI-H1648	lung	COSMIC	GKENK	DEG_APCC_KENBOX_2	0.1667
p.E498Q	HDQ-P1	breast	COSMIC	GKENK	DEG_APCC_KENBOX_2	0.6744
p.E497V	NCI-H1648	lung	COSMIC	GKENK	DEG_APCC_KENBOX_2	0.7693

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11142	Heat shock cognate 71 kDa protein	DEG_APCC_KENBOX_2	496:500	GKENK	APC,CDC20,FZR1	0.8507	More...
P54652	Heat shock-related 70 kDa protein 2	DEG_APCC_KENBOX_2	499:503	GKENK	APC,CDC20,FZR1	0.7207	More...
Q96QD5	DEP domain-containing protein 7	DEG_APCC_KENBOX_2	145:149	GKENK	APC,CDC20,FZR1	0.7832	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons