DegronMD

Uniprot ID: P54652

Source protein: Heat shock-related 70 kDa protein 2

Source gene: HSPA2

Class: DEG_APCC_KENBOX_2

Location: 499:503

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7207

ASA_SCORE: 95.68

COIL: 0.4062

CONS_SCORE: 0.779

DSS_SCORE: 0.4379

HELIX: 0.0042

FCONS_SCORE: 0.9011

RIG_SCORE: 0.7308

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A493T	TCGA-AP-A1DV	UCEC	TCGA	GKENK	DEG_APCC_KENBOX_2	0.1667
p.A493T	DO43186	UCEC	ICGC	GKENK	DEG_APCC_KENBOX_2	0.1667
p.G499S	DO222419	BTCA	ICGC	GKENK	DEG_APCC_KENBOX_2	0.5882
p.G511V	DO229015	LICA	ICGC	GKENK	DEG_APCC_KENBOX_2	0.1111
p.D509G	DO23538	LIRI	ICGC	GKENK	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11142	Heat shock cognate 71 kDa protein	DEG_APCC_KENBOX_2	496:500	GKENK	APC,CDC20,FZR1	0.8507	More...
P54652	Heat shock-related 70 kDa protein 2	DEG_APCC_KENBOX_2	499:503	GKENK	APC,CDC20,FZR1	0.7207	More...
Q96QD5	DEP domain-containing protein 7	DEG_APCC_KENBOX_2	145:149	GKENK	APC,CDC20,FZR1	0.7832	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons