DegronMD - Q96RE9(ZNF300)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S231G	TCGA-38-4632	LUAD	TCGA	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1389
p.S231G	DO23858	LUAD	ICGC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1389
p.H251Y	TCGA-67-3771	LUAD	TCGA	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1111
p.H251Y	DO25797	LUAD	ICGC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1111
p.S239N	TCGA-A5-A0G2	UCEC	TCGA	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation altering degron motif	0.7069
p.S239N	DO41235	UCEC	ICGC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation altering degron motif	0.7069
p.E248Q	TCGA-CR-6484	HNSC	TCGA	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1944
p.P228H	TCGA-DU-6392	LGG	TCGA	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.0556
p.P228H	DO22237	LGG	ICGC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.0556
p.P228H	DO229032	LICA	ICGC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.0556
p.D229N	TCGA-FR-A726	SKCM	TCGA	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.0833
p.D229N	DO48665	SKCM	ICGC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.0833
p.G253V	TCGA-IB-7651	PAAD	TCGA	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.0556
p.G253V	DO46657	PAAD	ICGC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.0556
p.Q230P	TCGA-V5-A7RC	ESCA	TCGA	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1111
p.V249I	DO223011	ESCA	ICGC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1667
p.V249I	DO40804	UCEC	ICGC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1667
p.V249I	DO41614	UCEC	ICGC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1667
p.P243L	DO23440	LINC	ICGC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation altering degron motif	0.7582
p.N248H	DO43306	UCEC	ICGC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.1944
p.G233R	SIDM00338	Acute Myeloid Leukemia	GDSC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation substituting flanking lysine	0.3056
p.G233R	SIDM00581	Glioblastoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation substituting flanking lysine	0.3056
p.G233R	SIDM00560	Gastric Carcinoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation substituting flanking lysine	0.3056
p.G233R	SIDM00543	Melanoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation substituting flanking lysine	0.3056
p.G233R	SIDM00243	Other Solid Cancers	GDSC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation substituting flanking lysine	0.3056
p.G233R	SIDM01728	Endometrial Carcinoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation substituting flanking lysine	0.3056
p.G233R	SIDM01761	Rhabdomyosarcoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation substituting flanking lysine	0.3056
p.P228S	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.0556
p.P228S	BEN	lung	COSMIC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.0556
p.E242A	SIDM00014	Colorectal Carcinoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation altering degron motif	0.7701
p.E242A	LIM1215	large intestine	COSMIC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation altering degron motif	0.7701
p.G234D	SIDM00849	Kidney Carcinoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.2222
p.G234D	A704	kidney	COSMIC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.2222
p.S241R	SIDM01564	Colorectal Carcinoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation altering degron motif	0.7427
p.G237V	ACH-001566	Skin Cancer	CCLE	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation rewiring degron network	0.3056
p.C238R	OSC-19	upper aerodigestive tract	COSMIC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation altering degron motif	0.8301
p.P240L	CP66-MEL	skin	COSMIC	VIPFDD	LIG_APCC_ABBA_1	238:243	Mutation altering degron motif	0.6471

Kaplan plot for ZNF300 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF300

UniProt ID: Q96RE9

Entrez ID: 91975

Protein name: Zinc finger protein 300

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF300 in