DegronMD

Uniprot ID: Q96RE9

Source protein: Zinc finger protein 300

Source gene: ZNF300

Class: LIG_APCC_ABBA_1

Location: 238:243

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.994

ASA_SCORE: 62.2

COIL: 0.8467

CONS_SCORE: 0.4701

DSS_SCORE: 0.3691

HELIX: 0.048

FCONS_SCORE: 0.8609

RIG_SCORE: 0.782

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S231G	TCGA-38-4632	LUAD	TCGA	VIPFDD	LIG_APCC_ABBA_1	0.1389
p.S231G	DO23858	LUAD	ICGC	VIPFDD	LIG_APCC_ABBA_1	0.1389
p.H251Y	TCGA-67-3771	LUAD	TCGA	VIPFDD	LIG_APCC_ABBA_1	0.1111
p.H251Y	DO25797	LUAD	ICGC	VIPFDD	LIG_APCC_ABBA_1	0.1111
p.S239N	TCGA-A5-A0G2	UCEC	TCGA	VIPFDD	LIG_APCC_ABBA_1	0.7069
p.S239N	DO41235	UCEC	ICGC	VIPFDD	LIG_APCC_ABBA_1	0.7069
p.E248Q	TCGA-CR-6484	HNSC	TCGA	VIPFDD	LIG_APCC_ABBA_1	0.1944
p.P228H	TCGA-DU-6392	LGG	TCGA	VIPFDD	LIG_APCC_ABBA_1	0.0556
p.P228H	DO22237	LGG	ICGC	VIPFDD	LIG_APCC_ABBA_1	0.0556
p.P228H	DO229032	LICA	ICGC	VIPFDD	LIG_APCC_ABBA_1	0.0556
p.D229N	TCGA-FR-A726	SKCM	TCGA	VIPFDD	LIG_APCC_ABBA_1	0.0833
p.D229N	DO48665	SKCM	ICGC	VIPFDD	LIG_APCC_ABBA_1	0.0833
p.G253V	TCGA-IB-7651	PAAD	TCGA	VIPFDD	LIG_APCC_ABBA_1	0.0556
p.G253V	DO46657	PAAD	ICGC	VIPFDD	LIG_APCC_ABBA_1	0.0556
p.Q230P	TCGA-V5-A7RC	ESCA	TCGA	VIPFDD	LIG_APCC_ABBA_1	0.1111
p.V249I	DO223011	ESCA	ICGC	VIPFDD	LIG_APCC_ABBA_1	0.1667
p.V249I	DO40804	UCEC	ICGC	VIPFDD	LIG_APCC_ABBA_1	0.1667
p.V249I	DO41614	UCEC	ICGC	VIPFDD	LIG_APCC_ABBA_1	0.1667
p.P243L	DO23440	LINC	ICGC	VIPFDD	LIG_APCC_ABBA_1	0.7582
p.N248H	DO43306	UCEC	ICGC	VIPFDD	LIG_APCC_ABBA_1	0.1944
p.G233R	SIDM00338	Acute Myeloid Leukemia	GDSC	VIPFDD	LIG_APCC_ABBA_1	0.3056
p.G233R	SIDM00581	Glioblastoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	0.3056
p.G233R	SIDM00560	Gastric Carcinoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	0.3056
p.G233R	SIDM00543	Melanoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	0.3056
p.G233R	SIDM00243	Other Solid Cancers	GDSC	VIPFDD	LIG_APCC_ABBA_1	0.3056
p.G233R	SIDM01728	Endometrial Carcinoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	0.3056
p.G233R	SIDM01761	Rhabdomyosarcoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	0.3056
p.P228S	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	0.0556
p.P228S	BEN	lung	COSMIC	VIPFDD	LIG_APCC_ABBA_1	0.0556
p.E242A	SIDM00014	Colorectal Carcinoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	0.7701
p.E242A	LIM1215	large_intestine	COSMIC	VIPFDD	LIG_APCC_ABBA_1	0.7701
p.G234D	SIDM00849	Kidney Carcinoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	0.2222
p.G234D	A704	kidney	COSMIC	VIPFDD	LIG_APCC_ABBA_1	0.2222
p.S241R	SIDM01564	Colorectal Carcinoma	GDSC	VIPFDD	LIG_APCC_ABBA_1	0.7427
p.G237V	ACH-001566	Skin Cancer	CCLE	VIPFDD	LIG_APCC_ABBA_1	0.3056
p.C238R	OSC-19	upper_aerodigestive_tract	COSMIC	VIPFDD	LIG_APCC_ABBA_1	0.8301
p.P240L	CP66-MEL	skin	COSMIC	VIPFDD	LIG_APCC_ABBA_1	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VIPFDD

Degron related mutations and impact score

Drug responses associated with ZNF300 mutations

All proteins holding degron of VIPFDD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RE9	Zinc finger protein 300	LIG_APCC_ABBA_1	238:243	VIPFDD	APC,CDC20,FZR1	0.994	More...