DegronMD - Q96RP7(GAL3ST4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S55T	TCGA-41-6646	GBM	TCGA	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.0556
p.S55T	DO14103	GBM	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.0556
p.R57L	TCGA-63-A5MS	LUSC	TCGA	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1111
p.R57L	DO219161	LUSC	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1111
p.R68L	TCGA-69-7973	LUAD	TCGA	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.7316
p.R68L	DO23870	LUAD	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.7316
p.R68L	ACH-002287	Colon/Colorectal Cancer	CCLE	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.7316
p.R68L	NCI-H630	large intestine	COSMIC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.7316
p.S81Y	TCGA-B5-A0JY	UCEC	TCGA	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1111
p.S81Y	DO43041	UCEC	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1111
p.L83V	DO219002	BLCA	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.0556
p.G58R	DO51612	CESC	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1389
p.S68F	DO23488	LINC	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.7982
p.P67L	DO45293	LIRI	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.7582
p.P74S	DO229179	LMS	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation blocking phosphorylation signal	0.75
p.P73S	DO23622	LUAD	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.6752
p.P61S	DO222837	MELA	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2222
p.R61Q	DO29228	OV	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2222
p.L62F	DO229446	SKCA	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation blocking phosphorylation signal	0.6944
p.P55S	DO37419	SKCM	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.0556
p.L83F	DO37406	SKCM	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.0556
p.S80R	DO219773	UCEC	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1389
p.A79T	DO41572	UCEC	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.1667
p.S68Y	DO42400	UCEC	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.712
p.S77F	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation blocking phosphorylation signal	0.6667
p.S77F	ACH-000920	Leukemia	CCLE	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation blocking phosphorylation signal	0.6667
p.S77F	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation blocking phosphorylation signal	0.6667
p.C63Y	SIDM00351	Oral Cavity Carcinoma	GDSC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.C63Y	ACH-002029	Head and Neck Cancer	CCLE	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.C63Y	SAS	upper aerodigestive tract	COSMIC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.2778
p.R66W	SIDM00814	Other Solid Cancers	GDSC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.8634
p.R66W	SIDM00209	Glioblastoma	GDSC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation altering degron motif	0.8634
p.L56F	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PRQRLVFLK	DEG_APCC_DBOX_1	65:73	Mutation rewiring degron network	0.0833

Kaplan plot for GAL3ST4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GAL3ST4

UniProt ID: Q96RP7

Entrez ID: 79690

Protein name: Galactose-3-O-sulfotransferase 4 (Gal3ST-4) (EC 2.8.2.-) (Beta-galactose-3-O-sulfotransferase 4) (Gal-beta-1,3-GalNAc 3'-sulfotransferase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GAL3ST4 in