DegronMD

Uniprot ID: Q96RP7

Source protein: Galactose-3-O-sulfotransferase 4

Source gene: GAL3ST4

Class: DEG_APCC_DBOX_1

Location: 65:73

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9524

ASA_SCORE: 48.4667

COIL: 0.2751

CONS_SCORE: 0.6883

DSS_SCORE: 0.461

HELIX: 0.0051

FCONS_SCORE: 1.0029

RIG_SCORE: 0.7596

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S55T	TCGA-41-6646	GBM	TCGA	PRQRLVFLK	DEG_APCC_DBOX_1	0.0556
p.S55T	DO14103	GBM	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.0556
p.R57L	TCGA-63-A5MS	LUSC	TCGA	PRQRLVFLK	DEG_APCC_DBOX_1	0.1111
p.R57L	DO219161	LUSC	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.1111
p.R68L	TCGA-69-7973	LUAD	TCGA	PRQRLVFLK	DEG_APCC_DBOX_1	0.7316
p.R68L	DO23870	LUAD	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.7316
p.R68L	ACH-002287	Colon/Colorectal Cancer	CCLE	PRQRLVFLK	DEG_APCC_DBOX_1	0.7316
p.R68L	NCI-H630	large_intestine	COSMIC	PRQRLVFLK	DEG_APCC_DBOX_1	0.7316
p.S81Y	TCGA-B5-A0JY	UCEC	TCGA	PRQRLVFLK	DEG_APCC_DBOX_1	0.1111
p.S81Y	DO43041	UCEC	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.1111
p.L83V	DO219002	BLCA	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.0556
p.G58R	DO51612	CESC	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.1389
p.S68F	DO23488	LINC	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.7982
p.P67L	DO45293	LIRI	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.7582
p.P74S	DO229179	LMS	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.75
p.P73S	DO23622	LUAD	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.6752
p.P61S	DO222837	MELA	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.2222
p.R61Q	DO29228	OV	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.2222
p.L62F	DO229446	SKCA	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.6944
p.P55S	DO37419	SKCM	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.0556
p.L83F	DO37406	SKCM	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.0556
p.S80R	DO219773	UCEC	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.1389
p.A79T	DO41572	UCEC	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.1667
p.S68Y	DO42400	UCEC	ICGC	PRQRLVFLK	DEG_APCC_DBOX_1	0.712
p.S77F	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PRQRLVFLK	DEG_APCC_DBOX_1	0.6667
p.S77F	ACH-000920	Leukemia	CCLE	PRQRLVFLK	DEG_APCC_DBOX_1	0.6667
p.S77F	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PRQRLVFLK	DEG_APCC_DBOX_1	0.6667
p.C63Y	SIDM00351	Oral Cavity Carcinoma	GDSC	PRQRLVFLK	DEG_APCC_DBOX_1	0.2778
p.C63Y	ACH-002029	Head and Neck Cancer	CCLE	PRQRLVFLK	DEG_APCC_DBOX_1	0.2778
p.C63Y	SAS	upper_aerodigestive_tract	COSMIC	PRQRLVFLK	DEG_APCC_DBOX_1	0.2778
p.R66W	SIDM00814	Other Solid Cancers	GDSC	PRQRLVFLK	DEG_APCC_DBOX_1	0.8634
p.R66W	SIDM00209	Glioblastoma	GDSC	PRQRLVFLK	DEG_APCC_DBOX_1	0.8634
p.L56F	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PRQRLVFLK	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRQRLVFLK

Degron related mutations and impact score

Drug responses associated with GAL3ST4 mutations

All proteins holding degron of PRQRLVFLK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RP7	Galactose-3-O-sulfotransferase 4	DEG_APCC_DBOX_1	65:73	PRQRLVFLK	APC,CDC20,FZR1	0.9524	More...