DegronMD - Q96S07(PRR25)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L195M	TCGA-55-8511	LUAD	TCGA	LSLHLE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.5999
p.L195M	DO24940	LUAD	ICGC	LSLHLE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.5999
p.P189T	TCGA-85-A50Z	LUSC	TCGA	LSLHLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1667
p.P189T	DO45462	LUSC	ICGC	LSLHLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1667
p.L199F	TCGA-EJ-7330	PRAD	TCGA	LSLHLE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.587
p.L199F	DO36237	PRAD	ICGC	LSLHLE	LIG_APCC_ABBA_1	195:200	Mutation altering degron motif	0.587
p.R208H	TCGA-HJ-7597	STAD	TCGA	LSLHLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.R208H	DO38195	STAD	ICGC	LSLHLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.G204C	DO228948	LICA	ICGC	LSLHLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.2222
p.L194P	DO50774	LIRI	ICGC	LSLHLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.3056
p.R208C	DO35242	PACA	ICGC	LSLHLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.1111
p.K201R	DO219872	SKCA	ICGC	LSLHLE	LIG_APCC_ABBA_1	195:200	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons