DegronMD

Uniprot ID: Q96S07

Source protein: Proline-rich protein 25

Source gene: PRR25

Class: LIG_APCC_ABBA_1

Location: 195:200

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6308

ASA_SCORE: 58.4833

COIL: 0.4037

CONS_SCORE: 0.9001

DSS_SCORE: 0.6094

HELIX: 0.145

FCONS_SCORE: 1.0448

RIG_SCORE: 0.7414

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L195M	TCGA-55-8511	LUAD	TCGA	LSLHLE	LIG_APCC_ABBA_1	0.5999
p.L195M	DO24940	LUAD	ICGC	LSLHLE	LIG_APCC_ABBA_1	0.5999
p.P189T	TCGA-85-A50Z	LUSC	TCGA	LSLHLE	LIG_APCC_ABBA_1	0.1667
p.P189T	DO45462	LUSC	ICGC	LSLHLE	LIG_APCC_ABBA_1	0.1667
p.L199F	TCGA-EJ-7330	PRAD	TCGA	LSLHLE	LIG_APCC_ABBA_1	0.587
p.L199F	DO36237	PRAD	ICGC	LSLHLE	LIG_APCC_ABBA_1	0.587
p.R208H	TCGA-HJ-7597	STAD	TCGA	LSLHLE	LIG_APCC_ABBA_1	0.1111
p.R208H	DO38195	STAD	ICGC	LSLHLE	LIG_APCC_ABBA_1	0.1111
p.G204C	DO228948	LICA	ICGC	LSLHLE	LIG_APCC_ABBA_1	0.2222
p.L194P	DO50774	LIRI	ICGC	LSLHLE	LIG_APCC_ABBA_1	0.3056
p.R208C	DO35242	PACA	ICGC	LSLHLE	LIG_APCC_ABBA_1	0.1111
p.K201R	DO219872	SKCA	ICGC	LSLHLE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96S07	Proline-rich protein 25	LIG_APCC_ABBA_1	195:200	LSLHLE	APC,CDC20,FZR1	0.6308	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons