DegronMD - Q96S42(NODAL)

GO - Biological processes (BP): axial mesodermal cell fate specification [GO:0048327]; BMP signaling pathway [GO:0030509]; brain development [GO:0007420]; cell migration involved in gastrulation [GO:0042074]; digestive tract morphogenesis [GO:0048546]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic pattern specification [GO:0009880]; embryonic placenta development [GO:0001892]; embryonic process involved in female pregnancy [GO:0060136]; endodermal cell differentiation [GO:0035987]; epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification [GO:0060802]; floor plate morphogenesis [GO:0033505]; formation of anatomical boundary [GO:0048859]; heart looping [GO:0001947]; inhibition of neuroepithelial cell differentiation [GO:0002085]; left lung morphogenesis [GO:0060460]; liver development [GO:0001889]; maternal placenta development [GO:0001893]; maternal process involved in parturition [GO:0060137]; mesendoderm development [GO:0048382]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of cell development [GO:0010721]; negative regulation of chorionic trophoblast cell proliferation [GO:1901383]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of trophoblast cell migration [GO:1901164]; neural fold formation [GO:0001842]; nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900164]; placenta development [GO:0001890]; polarity specification of proximal/distal axis [GO:0010085]; positive regulation of activin receptor signaling pathway [GO:0032927]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [GO:1900224]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of gastrulation [GO:0010470]; regulation of stem cell population maintenance [GO:2000036]; SMAD protein signal transduction [GO:0060395]; stem cell population maintenance [GO:0019827]; transforming growth factor beta receptor signaling pathway involved in primitive streak formation [GO:0090010]; trophectodermal cellular morphogenesis [GO:0001831]; vasculature development [GO:0001944] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P182L	TCGA-29-1711	OV	TCGA	PPTPPAT	DEG_SCF_FBW7_1	184:190	Mutation rewiring degron network	0.2778
p.P182L	DO30630	OV	ICGC	PPTPPAT	DEG_SCF_FBW7_1	184:190	Mutation rewiring degron network	0.2778
p.R175G	TCGA-2Y-A9H5	LIHC	TCGA	PPTPPAT	DEG_SCF_FBW7_1	184:190	Mutation rewiring degron network	0.0833
p.R175G	DO219529	LIHC	ICGC	PPTPPAT	DEG_SCF_FBW7_1	184:190	Mutation rewiring degron network	0.0833
p.R183Q	TCGA-AO-A128	BRCA	TCGA	PPTPPAT	DEG_SCF_FBW7_1	184:190	Mutation rewiring degron network	0.3056
p.R183Q	DO5326	BRCA	ICGC	PPTPPAT	DEG_SCF_FBW7_1	184:190	Mutation rewiring degron network	0.3056
p.P182S	TCGA-E6-A1M0	UCEC	TCGA	PPTPPAT	DEG_SCF_FBW7_1	184:190	Mutation rewiring degron network	0.2778
p.P182S	DO43682	UCEC	ICGC	PPTPPAT	DEG_SCF_FBW7_1	184:190	Mutation rewiring degron network	0.2778
p.R183W	TCGA-V5-AASX	ESCA	TCGA	PPTPPAT	DEG_SCF_FBW7_1	184:190	Mutation rewiring degron network	0.3056
p.P182T	DO25104	LUAD	ICGC	PPTPPAT	DEG_SCF_FBW7_1	184:190	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NODAL

UniProt ID: Q96S42

Entrez ID: 4838

Protein name: Nodal homolog

External links: UniprotKB HGNC RefSeq COSMIC

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