DegronMD

Uniprot ID: Q96S42

Source protein: Nodal homolog

Source gene: NODAL

Class: DEG_SCF_FBW7_1

Location: 184:190

E3 ligase: FBXW7

DEGRON score: 0.7419

ASA_SCORE: 80.5143

COIL: 0.8854

CONS_SCORE: 0.3645

DSS_SCORE: 0.3509

HELIX: 0.052

FCONS_SCORE: 0.8797

RIG_SCORE: 0.7016

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P182L	TCGA-29-1711	OV	TCGA	PPTPPAT	DEG_SCF_FBW7_1	0.2778
p.P182L	DO30630	OV	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.2778
p.R175G	TCGA-2Y-A9H5	LIHC	TCGA	PPTPPAT	DEG_SCF_FBW7_1	0.0833
p.R175G	DO219529	LIHC	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.0833
p.R183Q	TCGA-AO-A128	BRCA	TCGA	PPTPPAT	DEG_SCF_FBW7_1	0.3056
p.R183Q	DO5326	BRCA	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.3056
p.P182S	TCGA-E6-A1M0	UCEC	TCGA	PPTPPAT	DEG_SCF_FBW7_1	0.2778
p.P182S	DO43682	UCEC	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.2778
p.R183W	TCGA-V5-AASX	ESCA	TCGA	PPTPPAT	DEG_SCF_FBW7_1	0.3056
p.P182T	DO25104	LUAD	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13202	Dual specificity protein phosphatase 8	DEG_SCF_FBW7_1	361:367	PPTPPAT	FBXW7	0.8872	More...
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	215:221	PPTPPAT	FBXW7	0.8801	More...
Q96S42	Nodal homolog	DEG_SCF_FBW7_1	184:190	PPTPPAT	FBXW7	0.7419	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons