DegronMD

Uniprot ID: Q13202

Source protein: Dual specificity protein phosphatase 8

Source gene: DUSP8

Class: DEG_SCF_FBW7_1

Location: 361:367

E3 ligase: FBXW7

DEGRON score: 0.8872

ASA_SCORE: 86.0286

COIL: 0.921

CONS_SCORE: 0.2451

DSS_SCORE: 0.8324

HELIX: 0.0619

FCONS_SCORE: 0.9909

RIG_SCORE: 0.5818

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A369T	DO50440	ESAD	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.2778
p.T363M	DO233833	GACA	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.7423
p.P359L	DO222411	MELA	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.2778
p.P358H	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPTPPAT	DEG_SCF_FBW7_1	0.25
p.P358H	SIDM01681	Non-Cancerous	GDSC	PPTPPAT	DEG_SCF_FBW7_1	0.25
p.G356R	ACH-000943	Colon/Colorectal Cancer	CCLE	PPTPPAT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13202	Dual specificity protein phosphatase 8	DEG_SCF_FBW7_1	361:367	PPTPPAT	FBXW7	0.8872	More...
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	215:221	PPTPPAT	FBXW7	0.8801	More...
Q96S42	Nodal homolog	DEG_SCF_FBW7_1	184:190	PPTPPAT	FBXW7	0.7419	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons