DegronMD - Q13202(DUSP8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T316M	TCGA-2Y-A9H8	LIHC	TCGA	PGTPSGT	DEG_SCF_FBW7_1	310:316	Mutation altering degron motif	0.7423
p.T316M	TCGA-DD-AAE8	LIHC	TCGA	PGTPSGT	DEG_SCF_FBW7_1	310:316	Mutation altering degron motif	0.7423
p.T316M	DO52263	LIHC	ICGC	PGTPSGT	DEG_SCF_FBW7_1	310:316	Mutation altering degron motif	0.7423
p.T316M	DO219535	LIHC	ICGC	PGTPSGT	DEG_SCF_FBW7_1	310:316	Mutation altering degron motif	0.7423
p.P323A	TCGA-34-5231	LUSC	TCGA	PGTPSGT	DEG_SCF_FBW7_1	310:316	Mutation rewiring degron network	0.1389
p.P323A	DO26772	LUSC	ICGC	PGTPSGT	DEG_SCF_FBW7_1	310:316	Mutation rewiring degron network	0.1389
p.A305T	TCGA-CM-4744	COAD	TCGA	PGTPSGT	DEG_SCF_FBW7_1	310:316	Mutation rewiring degron network	0.1944
p.A305T	DO8882	COAD	ICGC	PGTPSGT	DEG_SCF_FBW7_1	310:316	Mutation rewiring degron network	0.1944
p.A369T	DO50440	ESAD	ICGC	PPTPPAT	DEG_SCF_FBW7_1	361:367	Mutation rewiring degron network	0.2778
p.T363M	DO233833	GACA	ICGC	PPTPPAT	DEG_SCF_FBW7_1	361:367	Mutation altering degron motif	0.7423
p.P359L	DO222411	MELA	ICGC	PPTPPAT	DEG_SCF_FBW7_1	361:367	Mutation rewiring degron network	0.2778
p.D309E	DO229143	NKTL	ICGC	PGTPSGT	DEG_SCF_FBW7_1	310:316	Mutation rewiring degron network	0.3056
p.P310L	DO229195	THCA	ICGC	PGTPSGT	DEG_SCF_FBW7_1	310:316	Mutation altering degron motif	0.6471
p.G326R	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PGTPSGT	DEG_SCF_FBW7_1	310:316	Mutation rewiring degron network	0.0556
p.G326R	ACH-000795	Leukemia	CCLE	PGTPSGT	DEG_SCF_FBW7_1	310:316	Mutation rewiring degron network	0.0556
p.L306R	SIDM00333	Endometrial Carcinoma	GDSC	PGTPSGT	DEG_SCF_FBW7_1	310:316	Mutation rewiring degron network	0.2222
p.L306R	ACH-000988	Endometrial/Uterine Cancer	CCLE	PGTPSGT	DEG_SCF_FBW7_1	310:316	Mutation rewiring degron network	0.2222
p.L306R	MFE-319	endometrium	COSMIC	PGTPSGT	DEG_SCF_FBW7_1	310:316	Mutation rewiring degron network	0.2222
p.P358H	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPTPPAT	DEG_SCF_FBW7_1	361:367	Mutation rewiring degron network	0.25
p.P358H	SIDM01681	Non-Cancerous	GDSC	PPTPPAT	DEG_SCF_FBW7_1	361:367	Mutation rewiring degron network	0.25
p.Q307R	ACH-000700	Lung Cancer	CCLE	PGTPSGT	DEG_SCF_FBW7_1	310:316	Mutation rewiring degron network	0.25
p.G356R	ACH-000943	Colon/Colorectal Cancer	CCLE	PPTPPAT	DEG_SCF_FBW7_1	361:367	Mutation rewiring degron network	0.1944

Kaplan plot for DUSP8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DUSP8

UniProt ID: Q13202

Entrez ID: 1850

Protein name: Dual specificity protein phosphatase 8 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH-5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DUSP8 in