DegronMD

Uniprot ID: Q13202

Source protein: Dual specificity protein phosphatase 8

Source gene: DUSP8

Class: DEG_SCF_FBW7_1

Location: 310:316

E3 ligase: FBXW7

DEGRON score: 0.9582

ASA_SCORE: 80.7571

COIL: 0.9713

CONS_SCORE: 0.2507

DSS_SCORE: 0.7983

HELIX: 0.0119

FCONS_SCORE: 0.9113

RIG_SCORE: 0.471

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T316M	TCGA-2Y-A9H8	LIHC	TCGA	PGTPSGT	DEG_SCF_FBW7_1	0.7423
p.T316M	TCGA-DD-AAE8	LIHC	TCGA	PGTPSGT	DEG_SCF_FBW7_1	0.7423
p.T316M	DO52263	LIHC	ICGC	PGTPSGT	DEG_SCF_FBW7_1	0.7423
p.T316M	DO219535	LIHC	ICGC	PGTPSGT	DEG_SCF_FBW7_1	0.7423
p.P323A	TCGA-34-5231	LUSC	TCGA	PGTPSGT	DEG_SCF_FBW7_1	0.1389
p.P323A	DO26772	LUSC	ICGC	PGTPSGT	DEG_SCF_FBW7_1	0.1389
p.A305T	TCGA-CM-4744	COAD	TCGA	PGTPSGT	DEG_SCF_FBW7_1	0.1944
p.A305T	DO8882	COAD	ICGC	PGTPSGT	DEG_SCF_FBW7_1	0.1944
p.D309E	DO229143	NKTL	ICGC	PGTPSGT	DEG_SCF_FBW7_1	0.3056
p.P310L	DO229195	THCA	ICGC	PGTPSGT	DEG_SCF_FBW7_1	0.6471
p.G326R	SIDM00433	T-Lymphoblastic Leukemia	GDSC	PGTPSGT	DEG_SCF_FBW7_1	0.0556
p.G326R	ACH-000795	Leukemia	CCLE	PGTPSGT	DEG_SCF_FBW7_1	0.0556
p.L306R	SIDM00333	Endometrial Carcinoma	GDSC	PGTPSGT	DEG_SCF_FBW7_1	0.2222
p.L306R	ACH-000988	Endometrial/Uterine Cancer	CCLE	PGTPSGT	DEG_SCF_FBW7_1	0.2222
p.L306R	MFE-319	endometrium	COSMIC	PGTPSGT	DEG_SCF_FBW7_1	0.2222
p.Q307R	ACH-000700	Lung Cancer	CCLE	PGTPSGT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13202	Dual specificity protein phosphatase 8	DEG_SCF_FBW7_1	310:316	PGTPSGT	FBXW7	0.9582	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons