DegronMD

Uniprot ID: Q8TAX7

Source protein: Mucin-7

Source gene: MUC7

Class: DEG_SCF_FBW7_1

Location: 215:221

E3 ligase: FBXW7

DEGRON score: 0.8801

ASA_SCORE: 94.1714

COIL: 0.9749

CONS_SCORE: 0.91

DSS_SCORE: 0.8151

HELIX: 0.008

FCONS_SCORE: 0.9812

RIG_SCORE: 0.4842

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A213S	TCGA-35-5375	LUAD	TCGA	PPTPPAT	DEG_SCF_FBW7_1	0.2778
p.A213S	DO25290	LUAD	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.2778
p.P216T	TCGA-CV-5443	HNSC	TCGA	PPTPPAT	DEG_SCF_FBW7_1	0.5919
p.P216T	DO15911	HNSC	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.5919
p.P215L	TCGA-DA-A95Z	SKCM	TCGA	PPTPPAT	DEG_SCF_FBW7_1	0.6471
p.P215L	DO219481	SKCM	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.6471
p.P215S	TCGA-DU-A5TW	LGG	TCGA	PPTPPAT	DEG_SCF_FBW7_1	0.6752
p.P215S	DO44572	LGG	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.6752
p.A230T	TCGA-EB-A4XL	SKCM	TCGA	PPTPPAT	DEG_SCF_FBW7_1	0.0833
p.A230T	DO47401	SKCM	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.0833
p.P218T	TCGA-LN-A9FP	ESCA	TCGA	PPTPPAT	DEG_SCF_FBW7_1	0.7031
p.P218L	TCGA-VQ-A8DL	STAD	TCGA	PPTPPAT	DEG_SCF_FBW7_1	0.7582
p.P218L	DO51750	STAD	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.7582
p.P219S	DO224721	COCA	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.5641
p.P219S	DO218242	GACA	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.5641
p.A207V	DO222521	MELA	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.1111
p.T221N	DO229221	THCA	ICGC	PPTPPAT	DEG_SCF_FBW7_1	0.7055
p.P223Q	SIDM01147	Gastric Carcinoma	GDSC	PPTPPAT	DEG_SCF_FBW7_1	0.2778
p.P209Q	NCI-H2110	lung	COSMIC	PPTPPAT	DEG_SCF_FBW7_1	0.1667
p.P209Q	SCaBER	urinary_tract	COSMIC	PPTPPAT	DEG_SCF_FBW7_1	0.1667
p.P209Q	NCI-N87	stomach	COSMIC	PPTPPAT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13202	Dual specificity protein phosphatase 8	DEG_SCF_FBW7_1	361:367	PPTPPAT	FBXW7	0.8872	More...
Q8TAX7	Mucin-7	DEG_SCF_FBW7_1	215:221	PPTPPAT	FBXW7	0.8801	More...
Q96S42	Nodal homolog	DEG_SCF_FBW7_1	184:190	PPTPPAT	FBXW7	0.7419	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons