DegronMD - Q96S90(LYSMD1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R213W	TCGA-AA-3864	COAD	TCGA	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.1667
p.R213W	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.1667
p.R213W	ACH-000482	Lung Cancer	CCLE	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.1667
p.R213W	RERF-LC-KJ	lung	COSMIC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.1667
p.P207S	TCGA-AX-A06F	UCEC	TCGA	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation altering degron motif	0.5641
p.Q198K	SIDM00557	Neuroblastoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM01004	Chronic Myelogenous Leukemia	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00582	Pancreatic Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00194	Colorectal Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM01040	Ovarian Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00291	Melanoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00308	Chronic Myelogenous Leukemia	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00193	Colorectal Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM01242	Melanoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00293	Small Cell Lung Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM01145	Gastric Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM01181	Hepatocellular Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00024	Non-Cancerous	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00498	Colorectal Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00526	Chronic Myelogenous Leukemia	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00276	Biliary Tract Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00502	B-Lymphoblastic Leukemia	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00357	Small Cell Lung Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00609	Kidney Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00907	Burkitt's Lymphoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM01210	Glioblastoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00217	Colorectal Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00986	Head and Neck Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00359	Colorectal Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00531	Pancreatic Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM01372	Pancreatic Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM01617	Endometrial Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM01577	Plasma Cell Myeloma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM01412	Oral Cavity Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM00169	Head and Neck Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM01781	Gastric Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.Q198K	SIDM01321	Pancreatic Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.3056
p.H191Q	SIDM00789	Colorectal Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.1111
p.H191Q	ACH-000997	Colon/Colorectal Cancer	CCLE	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.1111
p.H191Q	HCT-15	large intestine	COSMIC	QRAVLGPVP	DEG_APCC_DBOX_1	199:207	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LYSMD1

UniProt ID: Q96S90

Entrez ID: 388695

Protein name: LysM and putative peptidoglycan-binding domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LYSMD1 in