DegronMD

Uniprot ID: Q96S90

Source protein: LysM and putative peptidoglycan-binding domain-containing protein 1

Source gene: LYSMD1

Class: DEG_APCC_DBOX_1

Location: 199:207

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9962

ASA_SCORE: 83.8889

COIL: 0.7968

CONS_SCORE: 0.4727

DSS_SCORE: 0.49

HELIX: 0.1564

FCONS_SCORE: 1.13

RIG_SCORE: 0.7395

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R213W	TCGA-AA-3864	COAD	TCGA	QRAVLGPVP	DEG_APCC_DBOX_1	0.1667
p.R213W	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.1667
p.R213W	ACH-000482	Lung Cancer	CCLE	QRAVLGPVP	DEG_APCC_DBOX_1	0.1667
p.R213W	RERF-LC-KJ	lung	COSMIC	QRAVLGPVP	DEG_APCC_DBOX_1	0.1667
p.P207S	TCGA-AX-A06F	UCEC	TCGA	QRAVLGPVP	DEG_APCC_DBOX_1	0.5641
p.Q198K	SIDM00557	Neuroblastoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM01004	Chronic Myelogenous Leukemia	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00582	Pancreatic Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00194	Colorectal Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM01040	Ovarian Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00291	Melanoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00308	Chronic Myelogenous Leukemia	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00193	Colorectal Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM01242	Melanoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00293	Small Cell Lung Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM01145	Gastric Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM01181	Hepatocellular Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00024	Non-Cancerous	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00498	Colorectal Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00526	Chronic Myelogenous Leukemia	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00276	Biliary Tract Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00502	B-Lymphoblastic Leukemia	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00357	Small Cell Lung Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00609	Kidney Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00907	Burkitt's Lymphoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM01210	Glioblastoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00217	Colorectal Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00986	Head and Neck Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00359	Colorectal Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00531	Pancreatic Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM01372	Pancreatic Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM01617	Endometrial Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM01577	Plasma Cell Myeloma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM01412	Oral Cavity Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM00169	Head and Neck Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM01781	Gastric Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.Q198K	SIDM01321	Pancreatic Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.3056
p.H191Q	SIDM00789	Colorectal Carcinoma	GDSC	QRAVLGPVP	DEG_APCC_DBOX_1	0.1111
p.H191Q	ACH-000997	Colon/Colorectal Cancer	CCLE	QRAVLGPVP	DEG_APCC_DBOX_1	0.1111
p.H191Q	HCT-15	large_intestine	COSMIC	QRAVLGPVP	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRAVLGPVP

Degron related mutations and impact score

Drug responses associated with LYSMD1 mutations

All proteins holding degron of QRAVLGPVP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96S90	LysM and putative peptidoglycan-binding domain-containing protein 1	DEG_APCC_DBOX_1	199:207	QRAVLGPVP	APC,CDC20,FZR1	0.9962	More...