DegronMD - Q96SD1(DCLRE1C)

FUNCTION: Nuclease involved in DNA non-homologous end joining (NHEJ); required for double-strand break repair and V(D)J recombination (PubMed:11336668, PubMed:11955432, PubMed:12055248, PubMed:14744996, PubMed:15071507, PubMed:15574326, PubMed:15936993). Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments (PubMed:11336668, PubMed:11955432, PubMed:14744996). V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs) (PubMed:11336668, PubMed:11955432, PubMed:14744996). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends (PubMed:11336668, PubMed:11955432, PubMed:14744996). These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively (PubMed:11336668, PubMed:11955432, PubMed:14744996). This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC (PubMed:15071507, PubMed:15574326, PubMed:11955432, PubMed:15936993). The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint (PubMed:11955432). Also required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (PubMed:15456891, PubMed:15468306, PubMed:15574327, PubMed:15811628). {ECO:0000269|PubMed:11336668, ECO:0000269|PubMed:11955432, ECO:0000269|PubMed:12055248, ECO:0000269|PubMed:14744996, ECO:0000269|PubMed:15071507, ECO:0000269|PubMed:15456891, ECO:0000269|PubMed:15468306, ECO:0000269|PubMed:15574326, ECO:0000269|PubMed:15574327, ECO:0000269|PubMed:15811628, ECO:0000269|PubMed:15936993}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E665Q	TCGA-A2-A0EY	BRCA	TCGA	VPSTPEAE	DEG_SCF_FBW7_2	653:660	Mutation rewiring degron network	0.1944
p.R664Q	TCGA-AJ-A3EL	UCEC	TCGA	VPSTPEAE	DEG_SCF_FBW7_2	653:660	Mutation rewiring degron network	0.2222
p.P657L	SIDM00422	Hodgkin's Lymphoma	GDSC	VPSTPEAE	DEG_SCF_FBW7_2	653:660	Mutation altering degron motif	0.7582
p.P657L	ACH-001203	Lymphoma	CCLE	VPSTPEAE	DEG_SCF_FBW7_2	653:660	Mutation altering degron motif	0.7582
p.P657L	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	VPSTPEAE	DEG_SCF_FBW7_2	653:660	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCLRE1C

UniProt ID: Q96SD1

Entrez ID: 64421

Protein name: Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (Protein A-SCID) (SNM1 homolog C) (hSNM1C) (SNM1-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCLRE1C in