DegronMD

Uniprot ID: Q96SD1

Source protein: Protein artemis

Source gene: DCLRE1C

Class: DEG_SCF_FBW7_2

Location: 653:660

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 73.8875

COIL: 0.914

CONS_SCORE: 0.4436

DSS_SCORE: 0.6118

HELIX: 0.0431

FCONS_SCORE: 0.9963

RIG_SCORE: 0.6613

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E665Q	TCGA-A2-A0EY	BRCA	TCGA	VPSTPEAE	DEG_SCF_FBW7_2	0.1944
p.R664Q	TCGA-AJ-A3EL	UCEC	TCGA	VPSTPEAE	DEG_SCF_FBW7_2	0.2222
p.P657L	SIDM00422	Hodgkin's Lymphoma	GDSC	VPSTPEAE	DEG_SCF_FBW7_2	0.7582
p.P657L	ACH-001203	Lymphoma	CCLE	VPSTPEAE	DEG_SCF_FBW7_2	0.7582
p.P657L	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	VPSTPEAE	DEG_SCF_FBW7_2	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96SD1	Protein artemis	DEG_SCF_FBW7_2	653:660	VPSTPEAE	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons